Polo-like kinase 1 (Drosophila), also known as PLK1, is a human gene. The crystal structure of the kinase domain of a mutant form of the Plk1 protein was determined by Pfizer in 2007. [cite news | author=staff | title=Pfizer Discovers Crystal Structure of Plk1 | url= | format=paper
work=Genetics Engineering & Biotechnology News | publisher=Mary Ann Liebert, Inc. | page=28 | date=2007-06-15
] ["Note: full text is not available without subscription or purchase." cite journal | last=Kothe | first=Michael | coauthors=Darcy Kohls, Simon Low, Rocco Coli, Alan C. Cheng, "et al."
year=2007 | month=May | title=Structure of the Catalytic Domain of Human Polo-like Kinase 1
journal=Biochemistry | volume=46 | issue=20 | pages=5960–5971 | doi=10.1021/bi602474j
pmid=17461553 | url= | accessdate=2008-07-07
quote=(from abstract) We determined the crystal structures of the T210V mutant of the kinase domain of human Plk1 complexed with the nonhydrolyzable ATP analogue adenylylimidodiphosphate (AMPPNP) or the pyrrolo-pyrazole inhibitor PHA-680626 at 2.4 and 2.1 A resolution, respectively.

section_title =
summary_text =

ee also

* Polo like kinases, the gene family that PLK1 belongs to


citations =

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Proteinkinase PLK1 — Masse/Länge Primärstruktur 603 Aminosäuren …   Deutsch Wikipedia

  • NUDC — Nuclear distribution gene C homolog (A. nidulans) PDB rendering based on 2cr0 …   Wikipedia

  • Polo-like-Kinasen — (dt. „Polo ähnliche Kinasen“, PLK) sind wichtige Regulatorenzyme des Zellzyklus der Eukaryoten und wurden erstmalig 1993 bei der Taufliege beschrieben[1]. Die PLK sind an der Bildung und Änderung der mitotischen Spindel und an der Aktivierung des …   Deutsch Wikipedia

  • CHEK2 — CHK2 checkpoint homolog (S. pombe) PDB rendering based on 1gxc …   Wikipedia

  • MLF1IP — MLF1 interacting protein, also known as MLF1IP, is a human gene.cite web | title = Entrez Gene: MLF1IP MLF1 interacting protein| url = Cmd=ShowDetailView TermToSearch=79682| accessdate = ] PBB… …   Wikipedia

  • Spindle apparatus — This article is about the cellular structure. For other uses, see Spindle (disambiguation). Micrograph showing condensed chromosomes in blue and the mitotic spindle in green during prometaphase of mitosis In cell biology, the spindle fibers are… …   Wikipedia

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC Protein kinase A has several functions… …   Wikipedia

  • Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia

  • Keratin 4 — Identifiers Symbols KRT4; CK 4; CK4; CYK4; FLJ31692; K4 External IDs OMIM …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number CAS number 142243 02 5 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.