PLK1


PLK1

Polo-like kinase 1 (Drosophila), also known as PLK1, is a human gene. The crystal structure of the kinase domain of a mutant form of the Plk1 protein was determined by Pfizer in 2007. [cite news | author=staff | title=Pfizer Discovers Crystal Structure of Plk1 | url= | format=paper
work=Genetics Engineering & Biotechnology News | publisher=Mary Ann Liebert, Inc. | page=28 | date=2007-06-15
accessdate=2008-07-06
] ["Note: full text is not available without subscription or purchase." cite journal | last=Kothe | first=Michael | coauthors=Darcy Kohls, Simon Low, Rocco Coli, Alan C. Cheng, "et al."
year=2007 | month=May | title=Structure of the Catalytic Domain of Human Polo-like Kinase 1
journal=Biochemistry | volume=46 | issue=20 | pages=5960–5971 | doi=10.1021/bi602474j
pmid=17461553 | url= | accessdate=2008-07-07
quote=(from abstract) We determined the crystal structures of the T210V mutant of the kinase domain of human Plk1 complexed with the nonhydrolyzable ATP analogue adenylylimidodiphosphate (AMPPNP) or the pyrrolo-pyrazole inhibitor PHA-680626 at 2.4 and 2.1 A resolution, respectively.
]

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ee also

* Polo like kinases, the gene family that PLK1 belongs to

References

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