PPP2CA

Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform, also known as PPP2CA, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [cite web | title = Entrez Gene: PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5515| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cohen P, Cohen PT |title=Protein phosphatases come of age. |journal=J. Biol. Chem. |volume=264 |issue= 36 |pages= 21435–8 |year= 1990 |pmid= 2557326 |doi=
*cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=
*cite journal | author=Kamibayashi C, Lickteig RL, Estes R, "et al." |title=Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits. |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21864–72 |year= 1992 |pmid= 1328247 |doi=
*cite journal | author=Goedert M, Cohen ES, Jakes R, Cohen P |title=p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 95–9 |year= 1992 |pmid= 1330687 |doi=
*cite journal | author=Khew-Goodall Y, Mayer RE, Maurer F, "et al." |title=Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. |journal=Biochemistry |volume=30 |issue= 1 |pages= 89–97 |year= 1991 |pmid= 1846293 |doi=
*cite journal | author=Scheidtmann KH, Virshup DM, Kelly TJ |title=Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity. |journal=J. Virol. |volume=65 |issue= 4 |pages= 2098–101 |year= 1991 |pmid= 1848320 |doi=
*cite journal | author=Scheidtmann KH, Mumby MC, Rundell K, Walter G |title=Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 1996–2003 |year= 1991 |pmid= 1848668 |doi=
*cite journal | author=Virshup DM, Kauffman MG, Kelly TJ |title=Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3891–8 |year= 1990 |pmid= 2555176 |doi=
*cite journal | author=Arino J, Woon CW, Brautigan DL, "et al." |title=Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 12 |pages= 4252–6 |year= 1988 |pmid= 2837763 |doi=
*cite journal | author=Stone SR, Mayer R, Wernet W, "et al." |title=The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit. |journal=Nucleic Acids Res. |volume=16 |issue= 23 |pages= 11365 |year= 1989 |pmid= 2849764 |doi=
*cite journal | author=Carrey EA, Campbell DG, Hardie DG |title=Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. |journal=EMBO J. |volume=4 |issue= 13B |pages= 3735–42 |year= 1986 |pmid= 4092695 |doi=
*cite journal | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123–8 |year= 1995 |pmid= 7592815 |doi=
*cite journal | author=Favre B, Zolnierowicz S, Turowski P, Hemmings BA |title=The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. |journal=J. Biol. Chem. |volume=269 |issue= 23 |pages= 16311–7 |year= 1994 |pmid= 8206937 |doi=
*cite journal | author=Jones TA, Barker HM, da Cruz e Silva EF, "et al." |title=Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. |journal=Cytogenet. Cell Genet. |volume=63 |issue= 1 |pages= 35–41 |year= 1993 |pmid= 8383590 |doi=
*cite journal | author=Redpath NT, Price NT, Severinov KV, Proud CG |title=Regulation of elongation factor-2 by multisite phosphorylation. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 689–99 |year= 1993 |pmid= 8386634 |doi=
*cite journal | author=Muramatsu T, Kincaid RL |title=Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha). |journal=Biochim. Biophys. Acta |volume=1178 |issue= 1 |pages= 117–20 |year= 1993 |pmid= 8392375 |doi=
*cite journal | author=Kissinger CR, Parge HE, Knighton DR, "et al." |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |journal=Nature |volume=378 |issue= 6557 |pages= 641–4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0
*cite journal | author=Ohguro H, Rudnicka-Nawrot M, Buczyłko J, "et al." |title=Structural and enzymatic aspects of rhodopsin phosphorylation. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5215–24 |year= 1996 |pmid= 8617805 |doi=
*cite journal | author=McCright B, Rivers AM, Audlin S, Virshup DM |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22081–9 |year= 1996 |pmid= 8703017 |doi=

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