MAP3K7

Mitogen-activated protein kinase kinase kinase 7, also known as MAP3K7, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [cite web | title = Entrez Gene: MAP3K7 mitogen-activated protein kinase kinase kinase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6885| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=DuBridge RB, Tang P, Hsia HC, "et al." |title=Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. |journal=Mol. Cell. Biol. |volume=7 |issue= 1 |pages= 379–87 |year= 1987 |pmid= 3031469 |doi=
*cite journal | author=Hirose T, Fujimoto W, Tamaai T, "et al." |title=TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. |journal=Mol. Endocrinol. |volume=8 |issue= 12 |pages= 1667–80 |year= 1995 |pmid= 7708055 |doi=
*cite journal | author=Yamaguchi K, Shirakabe K, Shibuya H, "et al." |title=Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. |journal=Science |volume=270 |issue= 5244 |pages= 2008–11 |year= 1996 |pmid= 8533096 |doi=
*cite journal | author=Shibuya H, Yamaguchi K, Shirakabe K, "et al." |title=TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. |journal=Science |volume=272 |issue= 5265 |pages= 1179–82 |year= 1996 |pmid= 8638164 |doi=
*cite journal | author=Wang W, Zhou G, Hu MC, "et al." |title=Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22771–5 |year= 1997 |pmid= 9278437 |doi=
*cite journal | author=Liu X, Sun Y, Constantinescu SN, "et al." |title=Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 20 |pages= 10669–74 |year= 1997 |pmid= 9380693 |doi=
*cite journal | author=Kondo M, Osada H, Uchida K, "et al." |title=Molecular cloning of human TAK1 and its mutational analysis in human lung cancer. |journal=Int. J. Cancer |volume=75 |issue= 4 |pages= 559–63 |year= 1998 |pmid= 9466656 |doi=
*cite journal | author=Sakurai H, Shigemori N, Hasegawa K, Sugita T |title=TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 545–9 |year= 1998 |pmid= 9480845 |doi= 10.1006/bbrc.1998.8124
*cite journal | author=Yan ZH, Karam WG, Staudinger JL, "et al." |title=Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 10948–57 |year= 1998 |pmid= 9556573 |doi=
*cite journal | author=Lee FS, Peters RT, Dang LC, Maniatis T |title=MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9319–24 |year= 1998 |pmid= 9689078 |doi=
*cite journal | author=Yamaguchi K, Nagai S, Ninomiya-Tsuji J, "et al." |title=XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. |journal=EMBO J. |volume=18 |issue= 1 |pages= 179–87 |year= 1999 |pmid= 9878061 |doi= 10.1093/emboj/18.1.179
*cite journal | author=Lallena MJ, Diaz-Meco MT, Bren G, "et al." |title=Activation of IkappaB kinase beta by protein kinase C isoforms. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2180–8 |year= 1999 |pmid= 10022904 |doi=
*cite journal | author=Ninomiya-Tsuji J, Kishimoto K, Hiyama A, "et al." |title=The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. |journal=Nature |volume=398 |issue= 6724 |pages= 252–6 |year= 1999 |pmid= 10094049 |doi= 10.1038/18465
*cite journal | author=Sakurai H, Miyoshi H, Toriumi W, Sugita T |title=Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10641–8 |year= 1999 |pmid= 10187861 |doi=
*cite journal | author=Delhase M, Hayakawa M, Chen Y, Karin M |title=Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. |journal=Science |volume=284 |issue= 5412 |pages= 309–13 |year= 1999 |pmid= 10195894 |doi=
*cite journal | author=Zhou G, Lee SC, Yao Z, Tan TH |title=Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13133–8 |year= 1999 |pmid= 10224067 |doi=
*cite journal | author=Kimura N, Matsuo R, Shibuya H, "et al." |title=BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17647–52 |year= 2000 |pmid= 10748100 |doi= 10.1074/jbc.M908622199
*cite journal | author=Yamamoto Y, Yin MJ, Gaynor RB |title=IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3655–66 |year= 2000 |pmid= 10779355 |doi=
*cite journal | author=Hofer-Warbinek R, Schmid JA, Stehlik C, "et al." |title=Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22064–8 |year= 2000 |pmid= 10807933 |doi= 10.1074/jbc.M910346199
*cite journal | author=Sakurai H, Miyoshi H, Mizukami J, Sugita T |title=Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. |journal=FEBS Lett. |volume=474 |issue= 2-3 |pages= 141–5 |year= 2000 |pmid= 10838074 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes