HMGA1

HMGA1

High mobility group AT-hook 1, also known as HMGA1, is a human gene.

PBB_Summary
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summary_text = This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.cite web | title = Entrez Gene: HMGA1 high mobility group AT-hook 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3159| accessdate = ]

ee also

* HMGA

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Reeves R, Beckerbauer L |title=HMGI/Y proteins: flexible regulators of transcription and chromatin structure. |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1-2 |pages= 13–29 |year= 2001 |pmid= 11406267 |doi=
*cite journal | author=Hui H, Perfetti R |title=Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. |journal=Eur. J. Endocrinol. |volume=146 |issue= 2 |pages= 129–41 |year= 2002 |pmid= 11834421 |doi=
*cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26–43 |year= 2005 |pmid= 15875659 |doi=
*cite journal | author=Van Maele B, Busschots K, Vandekerckhove L, "et al." |title=Cellular co-factors of HIV-1 integration. |journal=Trends Biochem. Sci. |volume=31 |issue= 2 |pages= 98–105 |year= 2006 |pmid= 16403635 |doi= 10.1016/j.tibs.2005.12.002
*cite journal | author=Reeves R, Nissen MS |title=The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. |journal=J. Biol. Chem. |volume=265 |issue= 15 |pages= 8573–82 |year= 1990 |pmid= 1692833 |doi=
*cite journal | author=Nissen MS, Langan TA, Reeves R |title=Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19945–52 |year= 1991 |pmid= 1939057 |doi=
*cite journal | author=Eckner R, Birnstiel ML |title=Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif. |journal=Nucleic Acids Res. |volume=17 |issue= 15 |pages= 5947–59 |year= 1989 |pmid= 2505228 |doi=
*cite journal | author=Johnson KR, Lehn DA, Reeves R |title=Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y. |journal=Mol. Cell. Biol. |volume=9 |issue= 5 |pages= 2114–23 |year= 1989 |pmid= 2701943 |doi=
*cite journal | author=Palvimo J, Linnala-Kankkunen A |title=Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase II. |journal=FEBS Lett. |volume=257 |issue= 1 |pages= 101–4 |year= 1989 |pmid= 2806554 |doi=
*cite journal | author=Karlson JR, Mørk E, Holtlund J, "et al." |title=The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs. |journal=Biochem. Biophys. Res. Commun. |volume=158 |issue= 3 |pages= 646–51 |year= 1989 |pmid= 2920035 |doi=
*cite journal | author=Lund T, Dahl KH, Mørk E, "et al." |title=The human chromosomal protein HMG I contains two identical palindrome amino acid sequences. |journal=Biochem. Biophys. Res. Commun. |volume=146 |issue= 2 |pages= 725–30 |year= 1987 |pmid= 3619901 |doi=
*cite journal | author=Leger H, Sock E, Renner K, "et al." |title=Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3738–47 |year= 1995 |pmid= 7791781 |doi=
*cite journal | author=John S, Reeves RB, Lin JX, "et al." |title=Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1786–96 |year= 1995 |pmid= 7862168 |doi=
*cite journal | author=Friedmann M, Holth LT, Zoghbi HY, Reeves R |title=Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. |journal=Nucleic Acids Res. |volume=21 |issue= 18 |pages= 4259–67 |year= 1993 |pmid= 8414980 |doi=
*cite journal | author=Farnet CM, Bushman FD |title=HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro. |journal=Cell |volume=88 |issue= 4 |pages= 483–92 |year= 1997 |pmid= 9038339 |doi=
*cite journal | author=Miller MD, Farnet CM, Bushman FD |title=Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. |journal=J. Virol. |volume=71 |issue= 7 |pages= 5382–90 |year= 1997 |pmid= 9188609 |doi=
*cite journal | author=Huth JR, Bewley CA, Nissen MS, "et al." |title=The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif. |journal=Nat. Struct. Biol. |volume=4 |issue= 8 |pages= 657–65 |year= 1997 |pmid= 9253416 |doi=
*cite journal | author=Currie RA |title=Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y). |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30880–8 |year= 1998 |pmid= 9388234 |doi=
*cite journal | author=Chin MT, Pellacani A, Wang H, "et al." |title=Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 9755–60 |year= 1998 |pmid= 9545312 |doi=
*cite journal | author=Chiappetta G, Tallini G, De Biasio MC, "et al." |title=Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. |journal=Cancer Res. |volume=58 |issue= 18 |pages= 4193–8 |year= 1998 |pmid= 9751634 |doi=

External links

*

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