Interleukin 8 receptor, alpha

Chemokine (C-X-C motif) receptor 1
Rendering of 1ILP
Available structures PDB 1ILP, 1ILQ
Identifiers
Symbols	CXCR1; C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA
External IDs	OMIM: 146929 MGI: 2448715 HomoloGene: 68074 IUPHAR: GeneCards: CXCR1 Gene
Gene Ontology Molecular function • receptor activity • interleukin-8 receptor activity • G-protein coupled receptor activity • chemokine receptor activity • interleukin-8 binding Cellular component • plasma membrane • plasma membrane • membrane • integral to membrane Biological process • dendritic cell chemotaxis • chemotaxis • inflammatory response • cell surface receptor linked signaling pathway • G-protein coupled receptor protein signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3577	227288
Ensembl	ENSG00000163464	ENSMUSG00000048480
UniProt	P25024	n/a
RefSeq (mRNA)	NM_000634.2	NM_178241.4
RefSeq (protein)	NP_000625.1	NP_839972.1
Location (UCSC)	Chr 2: 219.03 – 219.03 Mb	Chr 1: 74.24 – 74.24 Mb
PubMed search	[1]	[2]

Interleukin 8 receptor, alpha is a chemokine receptor. IL8RA is its human gene. IL8RA has also been designated CD181 (cluster of differentiation 181), and CXCR1. CXCR1 is now the IUPHAR Committee on Receptor Nomenclature and Drug Classification recommended name.

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.^[1]

Clinical significance

Blocking CXCR1 (e.g. with repertaxin^[2]) inhibits some human breast cancer stem cells (in vitro and in mice).^[3]

See also

• Interleukin 8 receptor, beta
• Interleukin-8 receptor
• Interleukin 8
• Interleukin
• Interleukin receptor

Interactions

Interleukin 8 receptor, alpha has been shown to interact with GNAI2.^[4][5]

References

1. ^ "Entrez Gene: IL8RA interleukin 8 receptor, alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3577. 
2. ^ Casilli, F; Bianchini, A; Gloaguen, I; Biordi, L; Alesse, E; Festuccia, C; Cavalieri, B; Strippoli, R et al. (2005). "Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2". Biochemical pharmacology 69 (3): 385–94. doi:10.1016/j.bcp.2004.10.007. PMID 15652230. 
3. ^ http://www.genengnews.com/news/bnitem.aspx?name=72269134 "Investigators Find Method to Suppress Breast Cancer Stem Cells" Jan 2010
4. ^ Damaj, B B; McColl S R, Neote K, Songqing N, Ogborn K T, Hébert C A, Naccache P H (Oct. 1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB J. (UNITED STATES) 10 (12): 1426–34. ISSN 0892-6638. PMID 8903513. 
5. ^ Damaj, B B; McColl S R, Mahana W, Crouch M F, Naccache P H (May. 1996). "Physical association of Gi2alpha with interleukin-8 receptors". J. Biol. Chem. (UNITED STATES) 271 (22): 12783–9. doi:10.1074/jbc.271.22.12783. ISSN 0021-9258. PMID 8662698. 

External links

• "Chemokine Receptors: CXCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2210. 

Further_reading

• Ahuja SK, Ozçelik T, Milatovitch A et al. (1993). "Molecular evolution of the human interleukin-8 receptor gene cluster". Nat. Genet. 2 (1): 31–6. doi:10.1038/ng0992-31. PMID 1303245. 
• Lee J, Horuk R, Rice GC et al. (1992). "Characterization of two high affinity human interleukin-8 receptors". J. Biol. Chem. 267 (23): 16283–7. PMID 1379593. 
• Morris SW, Nelson N, Valentine MB et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896. 
• Holmes WE, Lee J, Kuang WJ et al. (1991). "Structure and functional expression of a human interleukin-8 receptor". Science 253 (5025): 1278–80. doi:10.1126/science.1840701. PMID 1840701. 
• Chuntharapai A, Lee J, Hébert CA, Kim KJ (1995). "Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes". J. Immunol. 153 (12): 5682–8. PMID 7527448. 
• Chuntharapai A, Kim KJ (1995). "Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor". J. Immunol. 155 (5): 2587–94. PMID 7650389. 
• Morohashi H, Miyawaki T, Nomura H et al. (1995). "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells". J. Leukoc. Biol. 57 (1): 180–7. PMID 7829970. 
• Schönbeck U, Brandt E, Petersen F et al. (1995). "IL-8 specifically binds to endothelial but not to smooth muscle cells". J. Immunol. 154 (5): 2375–83. PMID 7868904. 
• Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994). "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B". J. Biol. Chem. 269 (42): 26381–9. PMID 7929358. 
• Sprenger H, Lloyd AR, Meyer RG et al. (1994). "Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene". J. Immunol. 153 (6): 2524–32. PMID 8077663. 
• Schnitzel W, Monschein U, Besemer J (1994). "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B". J. Leukoc. Biol. 55 (6): 763–70. PMID 8195702. 
• Wu D, LaRosa GJ, Simon MI (1993). "G protein-coupled signal transduction pathways for interleukin-8". Science 261 (5117): 101–3. doi:10.1126/science.8316840. PMID 8316840. 
• Sebok K, Woodside D, al-Aoukaty A et al. (1993). "IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein". J. Immunol. 150 (4): 1524–34. PMID 8381837. 
• Cerretti DP, Kozlosky CJ, Vanden Bos T et al. (1993). "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2". Mol. Immunol. 30 (4): 359–67. doi:10.1016/0161-5890(93)90065-J. PMID 8384312. 
• Mollereau C, Muscatelli F, Mattei MG et al. (1993). "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor". Genomics 16 (1): 248–51. doi:10.1006/geno.1993.1167. PMID 8486366. 
• Lloyd A, Modi W, Sprenger H et al. (1993). "Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35". Cytogenet. Cell Genet. 63 (4): 238–40. doi:10.1159/000133541. PMID 8500355. 
• Damaj BB, McColl SR, Mahana W et al. (1996). "Physical association of Gi2alpha with interleukin-8 receptors". J. Biol. Chem. 271 (22): 12783–9. doi:10.1074/jbc.271.22.12783. PMID 8662698. 
• Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798. 
• Damaj BB, McColl SR, Neote K et al. (1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB J. 10 (12): 1426–34. PMID 8903513. 
• Jerva LF, Sullivan G, Lolis E (1997). "Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes". Protein Sci. 6 (8): 1643–52. doi:10.1002/pro.5560060805. PMC 2143775. PMID 9260277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2143775. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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