C-C chemokine receptor type 7

Chemokine (C-C motif) receptor 7
Identifiers
Symbols	CCR7; BLR2; CD197; CDw197; CMKBR7; EBI1
External IDs	OMIM: 600242 MGI: 103011 HomoloGene: 1387 IUPHAR: CCR7 GeneCards: CCR7 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • C-C chemokine receptor activity • chemokine (C-C motif) ligand 19 binding • chemokine (C-C motif) ligand 21 binding Cellular component • intracellular • plasma membrane • plasma membrane • plasma membrane • external side of plasma membrane • integral to membrane Biological process • establishment of T cell polarity • immunological synapse formation • positive regulation of cell-matrix adhesion • dendritic cell chemotaxis • myeloid dendritic cell chemotaxis • positive regulation of dendritic cell antigen processing and presentation • positive regulation of hypersensitivity • positive regulation of humoral immune response • chemotaxis • inflammatory response • immune response • G-protein coupled receptor protein signaling pathway • elevation of cytosolic calcium ion concentration • positive regulation of glycoprotein biosynthetic process • positive regulation of actin filament polymerization • positive regulation of pseudopodium assembly • T cell costimulation • ruffle organization • regulation of interferon-gamma production • positive regulation of interleukin-12 production • activation of Rho GTPase activity • response to prostaglandin E stimulus • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of cell adhesion • positive regulation of protein kinase activity • positive regulation of JNK cascade • cell maturation • regulation of interleukin-1 beta secretion • release of sequestered calcium ion into cytosol • positive regulation of filopodium assembly • positive regulation of protein kinase B signaling cascade • positive regulation of ERK1 and ERK2 cascade • response to nitric oxide • interleukin-12 secretion • positive regulation of neutrophil chemotaxis • lymphocyte migration into lymph node • negative regulation of leukocyte apoptosis • positive regulation of cell motility Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1236	12775
Ensembl	ENSG00000126353	ENSMUSG00000037944
UniProt	P32248	Q3U3J0
RefSeq (mRNA)	NM_001838.3	NM_007719.2
RefSeq (protein)	NP_001829.1	NP_031745.2
Location (UCSC)	Chr 17: 38.71 – 38.72 Mb	Chr 11: 99.01 – 99.02 Mb
PubMed search	[1]	[2]

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.^[1]

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells home to secondary lympho-organ, such as lympho-nodes, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ELC) has been reported to be a specific ligand of this receptor.^[2]

References

1. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol 67 (4): 2209–20. PMC 240341. PMID 8383238. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=240341. 
2. ^ "Entrez Gene: CCR7 chemokine (C-C motif) receptor 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1236. 

External links

• "Chemokine Receptors: CCR7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2232. 

Further reading

• Müller G, Lipp M (2003). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.". Microcirculation (New York, N.Y. : 1994) 10 (3–4): 325–34. doi:10.1038/sj.mn.7800197. PMID 12851649. 
• Burgstahler R, Kempkes B, Steube K, Lipp M (1995). "Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2". Biochem. Biophys. Res. Commun. 215 (2): 737–43. doi:10.1006/bbrc.1995.2525. PMID 7488016. 
• Schweickart VL, Raport CJ, Godiska R, et al. (1995). "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2". Genomics 23 (3): 643–50. doi:10.1006/geno.1994.1553. PMID 7851893. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Yoshida R, Imai T, Hieshima K, et al. (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236. 
• Yoshida R, Nagira M, Kitaura M, et al. (1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7". J. Biol. Chem. 273 (12): 7118–22. doi:10.1074/jbc.273.12.7118. PMID 9507024. 
• Campbell JJ, Bowman EP, Murphy K, et al. (1998). "6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7". J. Cell Biol. 141 (4): 1053–9. doi:10.1083/jcb.141.4.1053. PMC 2132769. PMID 9585422. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132769. 
• Kim CH, Pelus LM, White JR, Broxmeyer HE (1998). "Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells". J. Immunol. 161 (5): 2580–5. PMID 9725259. 
• Yanagihara S, Komura E, Nagafune J, et al. (1998). "EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation". J. Immunol. 161 (6): 3096–102. PMID 9743376. 
• Hasegawa H, Nomura T, Kohno M, et al. (2000). "Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells". Blood 95 (1): 30–8. PMID 10607681. 
• Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. PMID 10706668. 
• Agace WW, Roberts AI, Wu L, et al. (2000). "Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation". Eur. J. Immunol. 30 (3): 819–26. doi:10.1002/1521-4141(200003)30:3<819::AID-IMMU819>3.0.CO;2-Y. PMID 10741397. 
• Annunziato F, Romagnani P, Cosmi L, et al. (2000). "Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection". J. Immunol. 165 (1): 238–46. PMID 10861057. 
• Campbell JJ, Murphy KE, Kunkel EJ, et al. (2001). "CCR7 expression and memory T cell diversity in humans". J. Immunol. 166 (2): 877–84. PMID 11145663. 
• Campbell JJ, Qin S, Unutmaz D, et al. (2001). "Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire". J. Immunol. 166 (11): 6477–82. PMID 11359797. 
• Taylor JR, Kimbrell KC, Scoggins R, et al. (2001). "Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1". J. Virol. 75 (18): 8752–60. doi:10.1128/JVI.75.18.8752-8760.2001. PMC 115120. PMID 11507220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=115120. 
• Höpken UE, Foss HD, Meyer D, et al. (2002). "Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs". Blood 99 (4): 1109–16. doi:10.1182/blood.V99.4.1109. PMID 11830455. 
• Nakayama T, Fujisawa R, Izawa D, et al. (2002). "Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5". J. Virol. 76 (6): 3072–7. doi:10.1128/JVI.76.6.3072-3077.2002. PMC 135988. PMID 11861876. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=135988. 
• Till KJ, Lin K, Zuzel M, Cawley JC (2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes". Blood 99 (8): 2977–84. doi:10.1182/blood.V99.8.2977. PMID 11929789. 
• Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, et al. (2004). "Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells". Blood 104 (6): 619–625. doi:10.1182/blood-2003-11-3943. PMID 15059845. 
• Riol-Blanco L, Sánchez-Sánchez N, Torres A, et al. (2005). "The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed". J. Immunol. 174 (6): 4070–80. PMID 15778365. 
• Sánchez-Sánchez N, Riol-Blanco L, Rodríguez-Fernández JL (2006). "The multiple personalities of the chemokine receptor CCR7 in dendritic cells". J. Immunol. 176 (6): 5153–9. PMID 16621978. 
• Escribano C, Delgado-Martín C, Rodríguez-Fernández JL (2009). "CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta". J. Immunol. 183 (10): 6282–95. doi:10.4049/jimmunol.0804093. PMID 19841191. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

TNF receptor

1-10	TNFRSF1 (CD120) · TNFRSF1A (CD120a) · TNFRSF1B (CD120b) · TNFRSF3 (Lymphotoxin beta receptor) · TNFRSF4 (CD134) · TNFRSF5 (CD40) · TNFRSF6 (FAS) · TNFRSF6B · TNFRSF7 (CD27) · TNFRSF8 (CD30) · TNFRSF9 (CD137)
11-20	TNFRSF10A (CD261) · TNFRSF10B (CD262) · TNFRSF10C (CD263) · TNFRSF10D (CD264) · TNFRSF11A (CD265/RANK) · TNFRSF11B (Osteoprotegerin) · TNFRSF12A (CD266) · TNFRSF13B (CD267) · TNFRSF13C · TNFRSF14 (CD268) · TNFRSF16 (Nerve growth factor receptor) · TNFRSF17 (CD269) · TNFRSF18 · TNFRSF19
21-25	TNFRSF21 · TNFRSF25 · TNFRSF27

JAK-STAT

Type I	γ-chain Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R) β-chain Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF gp130 Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR IL12RB1 Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23) Other other CSF receptors (EPO, G-CSF, Thrombopoietin) hormone receptor: GH · prolactin
Type II	Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)

Ig superfamily

CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1

IL-17 family

IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)

S/T

TGF-beta (TGFBR1, TGFBR2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)