CDC25A

CDC25A

Cell division cycle 25 homolog A (S. pombe), also known as CDC25A, is a human gene.

PBB_Summary
section_title =
summary_text = CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: CDC25A cell division cycle 25 homolog A (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=993| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Parsons R |title=Phosphatases and tumorigenesis. |journal=Current opinion in oncology |volume=10 |issue= 1 |pages= 88–91 |year= 1998 |pmid= 9466490 |doi=
*cite journal | author=Kerkhoff E, Rapp UR |title=Cell cycle targets of Ras/Raf signalling. |journal=Oncogene |volume=17 |issue= 11 Reviews |pages= 1457–62 |year= 1998 |pmid= 9779991 |doi= 10.1038/sj.onc.1202185
*cite journal | author=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue= |pages= 107–14 |year= 2000 |pmid= 10740819 |doi=
*cite journal | author=Galaktionov K, Beach D |title=Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. |journal=Cell |volume=67 |issue= 6 |pages= 1181–94 |year= 1992 |pmid= 1836978 |doi=
*cite journal | author=Conklin DS, Galaktionov K, Beach D |title=14-3-3 proteins associate with cdc25 phosphatases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7892–6 |year= 1995 |pmid= 7644510 |doi=
*cite journal | author=Galaktionov K, Lee AK, Eckstein J, "et al." |title=CDC25 phosphatases as potential human oncogenes. |journal=Science |volume=269 |issue= 5230 |pages= 1575–7 |year= 1995 |pmid= 7667636 |doi=
*cite journal | author=Galaktionov K, Jessus C, Beach D |title=Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. |journal=Genes Dev. |volume=9 |issue= 9 |pages= 1046–58 |year= 1995 |pmid= 7744247 |doi=
*cite journal | author=Demetrick DJ, Beach DH |title=Chromosome mapping of human CDC25A and CDC25B phosphatases. |journal=Genomics |volume=18 |issue= 1 |pages= 144–7 |year= 1994 |pmid= 8276402 |doi= 10.1006/geno.1993.1440
*cite journal | author=Xu X, Burke SP |title=Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5118–24 |year= 1996 |pmid= 8617791 |doi=
*cite journal | author=Tiefenbrun N, Melamed D, Levy N, "et al." |title=Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3934–44 |year= 1996 |pmid= 8668211 |doi=
*cite journal | author=Huang TS, Shu CH, Yang WK, Whang-Peng J |title=Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis. |journal=Cancer Res. |volume=57 |issue= 14 |pages= 2974–8 |year= 1997 |pmid= 9230211 |doi=
*cite journal | author=Fauman EB, Cogswell JP, Lovejoy B, "et al." |title=Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. |journal=Cell |volume=93 |issue= 4 |pages= 617–25 |year= 1998 |pmid= 9604936 |doi=
*cite journal | author=Coqueret O, Bérubé G, Nepveu A |title=The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase. |journal=EMBO J. |volume=17 |issue= 16 |pages= 4680–94 |year= 1998 |pmid= 9707427 |doi= 10.1093/emboj/17.16.4680
*cite journal | author=Iavarone A, Massagué J |title=E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 916–22 |year= 1999 |pmid= 9858615 |doi=
*cite journal | author=Sexl V, Diehl JA, Sherr CJ, "et al." |title=A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. |journal=Oncogene |volume=18 |issue= 3 |pages= 573–82 |year= 1999 |pmid= 9989807 |doi= 10.1038/sj.onc.1202362
*cite journal | author=Mochizuki T, Kitanaka C, Noguchi K, "et al." |title=Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18659–66 |year= 1999 |pmid= 10373478 |doi=
*cite journal | author=Xia K, Lee RS, Narsimhan RP, "et al." |title=Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4819–24 |year= 1999 |pmid= 10373531 |doi=
*cite journal | author=Vigo E, Müller H, Prosperini E, "et al." |title=CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6379–95 |year= 1999 |pmid= 10454584 |doi=

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