DCTN1


DCTN1
Dynactin 1

PDB rendering based on 1txq.
Identifiers
Symbols DCTN1; DAP-150; DP-150; P135
External IDs OMIM601143 MGI107745 HomoloGene3011 GeneCards: DCTN1 Gene
RNA expression pattern
PBB GE DCTN1 201082 s at tn.png
PBB GE DCTN1 211780 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1639 13191
Ensembl ENSG00000204843 ENSMUSG00000031865
UniProt Q14203 Q3T9V8
RefSeq (mRNA) NM_001135040.2 XM_977604
RefSeq (protein) NP_001128512.1 XP_982698
Location (UCSC) Chr 2:
74.59 – 74.62 Mb
Chr 6:
83.12 – 83.15 Mb
PubMed search [1] [2]

Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene.[1]

Contents

Function

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.[2]

Interactions

DCTN1 has been shown to interact with BBS4,[3] RAB6A,[4] Grb2[5] and Dystonin.[6]

References

  1. ^ Holzbaur EL, Hammarback JA, Paschal BM, Kravit NG, Pfister KK, Vallee RB (Jul 1991). "Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued". Nature 351 (6327): 579–83. doi:10.1038/351579a0. PMID 1828535. 
  2. ^ "Entrez Gene: DCTN1 dynactin 1 (p150, glued homolog, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1639. 
  3. ^ Kim, Jun Chul; Badano Jose L, Sibold Sonja, Esmail Muneer A, Hill Josephine, Hoskins Bethan E, Leitch Carmen C, Venner Kerrie, Ansley Stephen J, Ross Alison J, Leroux Michel R, Katsanis Nicholas, Beales Philip L (May. 2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression". Nat. Genet. (United States) 36 (5): 462–70. doi:10.1038/ng1352. ISSN 1061-4036. PMID 15107855. 
  4. ^ Short, Benjamin; Preisinger Christian, Schaletzky Julia, Kopajtich Robert, Barr Francis A (Oct. 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. (England) 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. ISSN 0960-9822. PMID 12401177. 
  5. ^ Sahni, M; Zhou X M, Bakiri L, Schlessinger J, Baron R, Levy J B (Dec. 1996). "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". J. Biol. Chem. (UNITED STATES) 271 (51): 33141–7. doi:10.1074/jbc.271.51.33141. ISSN 0021-9258. PMID 8955163. 
  6. ^ Liu, Jia-Jia; Ding Jianqing, Kowal Anthony S, Nardine Timothy, Allen Elizabeth, Delcroix Jean-Dominique, Wu Chengbiao, Mobley William, Fuchs Elaine, Yang Yanmin (Oct. 2003). "BPAG1n4 is essential for retrograde axonal transport in sensory neurons". J. Cell Biol. (United States) 163 (2): 223–9. doi:10.1083/jcb.200306075. ISSN 0021-9525. PMC 2173519. PMID 14581450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173519. 

Further reading

External Links



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