PLD2

PLD2

Phospholipase D2, also known as PLD2, is a human gene.

PBB_Summary
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summary_text = Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. [supplied by OMIM] cite web | title = Entrez Gene: PLD2 phospholipase D2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5338| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sundaram M, Cook HW, Byers DM |title=The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular components. |journal=Biochem. Cell Biol. |volume=82 |issue= 1 |pages= 191–200 |year= 2004 |pmid= 15052337 |doi= 10.1139/o03-087
*cite journal | author=McDermott M, Wakelam MJ, Morris AJ |title=Phospholipase D. |journal=Biochem. Cell Biol. |volume=82 |issue= 1 |pages= 225–53 |year= 2004 |pmid= 15052340 |doi= 10.1139/o03-079
*cite journal | author=Colley WC, Sung TC, Roll R, "et al." |title=Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. |journal=Curr. Biol. |volume=7 |issue= 3 |pages= 191–201 |year= 1997 |pmid= 9395408 |doi=
*cite journal | author=Lopez I, Arnold RS, Lambeth JD |title=Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 12846–52 |year= 1998 |pmid= 9582313 |doi=
*cite journal | author=Steed PM, Clark KL, Boyar WC, Lasala DJ |title=Characterization of human PLD2 and the analysis of PLD isoform splice variants. |journal=FASEB J. |volume=12 |issue= 13 |pages= 1309–17 |year= 1998 |pmid= 9761774 |doi=
*cite journal | author=Slaaby R, Jensen T, Hansen HS, "et al." |title=PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33722–7 |year= 1999 |pmid= 9837959 |doi=
*cite journal | author=Park SH, Ryu SH, Suh PG, Kim H |title=Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 225 |year= 1999 |pmid= 9858823 |doi=
*cite journal | author=Czarny M, Fiucci G, Lavie Y, "et al." |title=Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains. |journal=FEBS Lett. |volume=467 |issue= 2-3 |pages= 326–32 |year= 2000 |pmid= 10675563 |doi=
*cite journal | author=Lee C, Kim SR, Chung JK, "et al." |title=Inhibition of phospholipase D by amphiphysins. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18751–8 |year= 2000 |pmid= 10764771 |doi= 10.1074/jbc.M001695200
*cite journal | author=Park JB, Kim JH, Kim Y, "et al." |title=Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21295–301 |year= 2000 |pmid= 10801846 |doi= 10.1074/jbc.M002463200
*cite journal | author=Zhang Y, Redina O, Altshuller YM, "et al." |title=Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35224–32 |year= 2001 |pmid= 10926929 |doi= 10.1074/jbc.M003329200
*cite journal | author=Morash SC, Byers DM, Cook HW |title=Activation of phospholipase D by PKC and GTPgammaS in human neuroblastoma cells overexpressing MARCKS. |journal=Biochim. Biophys. Acta |volume=1487 |issue= 2-3 |pages= 177–89 |year= 2000 |pmid= 11018470 |doi=
*cite journal | author=Divecha N, Roefs M, Halstead JR, "et al." |title=Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. |journal=EMBO J. |volume=19 |issue= 20 |pages= 5440–9 |year= 2000 |pmid= 11032811 |doi= 10.1093/emboj/19.20.5440
*cite journal | author=Slaaby R, Du G, Altshuller YM, "et al." |title=Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade. |journal=Biochem. J. |volume=351 Pt 3 |issue= |pages= 613–9 |year= 2001 |pmid= 11042115 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Lee S, Park JB, Kim JH, "et al." |title=Actin directly interacts with phospholipase D, inhibiting its activity. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28252–60 |year= 2001 |pmid= 11373276 |doi= 10.1074/jbc.M008521200
*cite journal | author=Sarkar S, Miwa N, Kominami H, "et al." |title=Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator. |journal=Biochem. J. |volume=359 |issue= Pt 3 |pages= 599–604 |year= 2001 |pmid= 11672434 |doi=
*cite journal | author=Denmat-Ouisse LA, Phebidias C, Honkavaara P, "et al." |title=Regulation of constitutive protein transit by phospholipase D in HT29-cl19A cells. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48840–6 |year= 2002 |pmid= 11687572 |doi= 10.1074/jbc.M104276200
*cite journal | author=Lee S, Kim JH, Lee CS, "et al." |title=Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6542–9 |year= 2002 |pmid= 11741937 |doi= 10.1074/jbc.M108047200
*cite journal | author=Han JM, Kim JH, Lee BD, "et al." |title=Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8290–7 |year= 2002 |pmid= 11744693 |doi= 10.1074/jbc.M108343200

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