- RUNX3
Runt-related transcription factor 3, also known as RUNX3, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: RUNX3 runt-related transcription factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=864| accessdate = ]Knockout mouse
Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation. [cite web | title = Entrez Gene: Causal relationship between the loss of RUNX3 expression and gastric cancer.| url = http://www.ncbi.nlm.nih.gov/pubmed/11955451?dopt=Abstract&holding=npg/pubmed/ 11955451| accessdate = ]
ee also
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Core binding factor
*RUNX1
*RUNX2 References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Vogiatzi P, De Falco G, Claudio PP, Giordano A |title=How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions. |journal=Cancer Biol. Ther. |volume=5 |issue= 4 |pages= 371–4 |year= 2007 |pmid= 16627973 |doi=
*cite journal | author=Wijmenga C, Speck NA, Dracopoli NC, "et al." |title=Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. |journal=Genomics |volume=26 |issue= 3 |pages= 611–4 |year= 1995 |pmid= 7607690 |doi=
*cite journal | author=Bae SC, Takahashi E, Zhang YW, "et al." |title=Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. |journal=Gene |volume=159 |issue= 2 |pages= 245–8 |year= 1995 |pmid= 7622058 |doi=
*cite journal | author=Levanon D, Negreanu V, Bernstein Y, "et al." |title=AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. |journal=Genomics |volume=23 |issue= 2 |pages= 425–32 |year= 1995 |pmid= 7835892 |doi= 10.1006/geno.1994.1519
*cite journal | author=Bae SC, Yamaguchi-Iwai Y, Ogawa E, "et al." |title=Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. |journal=Oncogene |volume=8 |issue= 3 |pages= 809–14 |year= 1993 |pmid= 8437866 |doi=
*cite journal | author=Levanon D, Goldstein RE, Bernstein Y, "et al." |title=Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11590–5 |year= 1998 |pmid= 9751710 |doi=
*cite journal | author=Bangsow C, Rubins N, Glusman G, "et al." |title=The RUNX3 gene--sequence, structure and regulated expression. |journal=Gene |volume=279 |issue= 2 |pages= 221–32 |year= 2002 |pmid= 11733147 |doi=
*cite journal | author=Li QL, Ito K, Sakakura C, "et al." |title=Causal relationship between the loss of RUNX3 expression and gastric cancer. |journal=Cell |volume=109 |issue= 1 |pages= 113–24 |year= 2002 |pmid= 11955451 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Waki T, Tamura G, Sato M, "et al." |title=Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia. |journal=Cancer Sci. |volume=94 |issue= 4 |pages= 360–4 |year= 2003 |pmid= 12824905 |doi=
*cite journal | author=Puig-Kröger A, Sanchez-Elsner T, Ruiz N, "et al." |title=RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements. |journal=Blood |volume=102 |issue= 9 |pages= 3252–61 |year= 2004 |pmid= 12855590 |doi= 10.1182/blood-2003-02-0618
*cite journal | author=Kato N, Tamura G, Fukase M, "et al." |title=Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 387–91 |year= 2003 |pmid= 12875960 |doi=
*cite journal | author=Yang N, Zhang L, Zhang Y, Kazazian HH |title=An important role for RUNX3 in human L1 transcription and retrotransposition. |journal=Nucleic Acids Res. |volume=31 |issue= 16 |pages= 4929–40 |year= 2004 |pmid= 12907736 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Li QL, Kim HR, Kim WJ, "et al." |title=Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 1 |pages= 223–8 |year= 2004 |pmid= 14715269 |doi=
*cite journal | author=Xiao WH, Liu WW |title=Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma. |journal=World J. Gastroenterol. |volume=10 |issue= 3 |pages= 376–80 |year= 2004 |pmid= 14760761 |doi=
*cite journal | author=Oshimo Y, Oue N, Mitani Y, "et al." |title=Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma. |journal=Pathobiology |volume=71 |issue= 3 |pages= 137–43 |year= 2004 |pmid= 15051926 |doi= 10.1159/000076468
*cite journal | author=Jin YH, Jeon EJ, Li QL, "et al." |title=Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29409–17 |year= 2004 |pmid= 15138260 |doi= 10.1074/jbc.M313120200
*cite journal | author=Ku JL, Kang SB, Shin YK, "et al." |title=Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. |journal=Oncogene |volume=23 |issue= 40 |pages= 6736–42 |year= 2004 |pmid= 15273736 |doi= 10.1038/sj.onc.1207731
*cite journal | author=Sakakura C, Hagiwara A, Miyagawa K, "et al." |title=Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. |journal=Int. J. Cancer |volume=113 |issue= 2 |pages= 221–8 |year= 2005 |pmid= 15386419 |doi= 10.1002/ijc.20551External links
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PBB_Controls
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