ICAM3

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.cite web | title = Entrez Gene: ICAM3 intercellular adhesion molecule 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3385| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Simmons DL |title=The role of ICAM expression in immunity and disease. |journal=Cancer Surv. |volume=24 |issue= |pages= 141–55 |year= 1995 |pmid= 7553659 |doi=
*cite journal | author=Hayflick JS, Kilgannon P, Gallatin WM |title=The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions. |journal=Immunol. Res. |volume=17 |issue= 3 |pages= 313–27 |year= 1998 |pmid= 9638475 |doi=
*cite journal | author=Fawcett J, Holness CL, Needham LA, "et al." |title=Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. |journal=Nature |volume=360 |issue= 6403 |pages= 481–4 |year= 1992 |pmid= 1448173 |doi= 10.1038/360481a0
*cite journal | author=Vazeux R, Hoffman PA, Tomita JK, "et al." |title=Cloning and characterization of a new intercellular adhesion molecule ICAM-R. |journal=Nature |volume=360 |issue= 6403 |pages= 485–8 |year= 1992 |pmid= 1448174 |doi= 10.1038/360485a0
*cite journal | author=Pino-Otín MR, Juan M, de la Fuente MA, "et al." |title=CD50 (intercellular adhesion molecule-3) is expressed at higher levels on memory than on naive human T cells but induces a similar calcium mobilization on both subsets. |journal=Tissue Antigens |volume=46 |issue= 1 |pages= 32–44 |year= 1995 |pmid= 7482494 |doi=
*cite journal | author=Marazuela M, Postigo AA, Acevedo A, "et al." |title=Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves' and Hashimoto's thyroid glands. |journal=Eur. J. Immunol. |volume=24 |issue= 10 |pages= 2483–90 |year= 1994 |pmid= 7523142 |doi=
*cite journal | author=Holness CL, Bates PA, Little AJ, "et al." |title=Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 877–84 |year= 1995 |pmid= 7822326 |doi=
*cite journal | author=Martin S, Rieckmann P, Melchers I, "et al." |title=Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1. |journal=J. Immunol. |volume=154 |issue= 4 |pages= 1951–5 |year= 1995 |pmid= 7836774 |doi=
*cite journal | author=Bossy D, Mattei MG, Simmons DL |title=The human intercellular adhesion molecule 3 (ICAM3) gene is located in the 19p13.2-p13.3 region, close to the ICAM1 gene. |journal=Genomics |volume=23 |issue= 3 |pages= 712–3 |year= 1995 |pmid= 7851905 |doi= 10.1006/geno.1994.1565
*cite journal | author=Skubitz KM, Ahmed K, Campbell KD, Skubitz AP |title=CD50 (ICAM-3) is phosphorylated on tyrosine and is associated with tyrosine kinase activity in human neutrophils. |journal=J. Immunol. |volume=154 |issue= 6 |pages= 2888–95 |year= 1995 |pmid= 7876557 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Juan M, Vilella R, Mila J, "et al." |title=CDw50 and ICAM-3: two names for the same molecule. |journal=Eur. J. Immunol. |volume=23 |issue= 7 |pages= 1508–12 |year= 1993 |pmid= 8325327 |doi=
*cite journal | author=de Fougerolles AR, Klickstein LB, Springer TA |title=Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1. |journal=J. Exp. Med. |volume=177 |issue= 4 |pages= 1187–92 |year= 1993 |pmid= 8459213 |doi=
*cite journal | author=Hosaka S, Shah MR, Pope RM, Koch AE |title=Soluble forms of P-selectin and intercellular adhesion molecule-3 in synovial fluids. |journal=Clin. Immunol. Immunopathol. |volume=78 |issue= 3 |pages= 276–82 |year= 1996 |pmid= 8605703 |doi=
*cite journal | author=Van der Vieren M, Le Trong H, Wood CL, "et al." |title=A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3. |journal=Immunity |volume=3 |issue= 6 |pages= 683–90 |year= 1996 |pmid= 8777714 |doi=
*cite journal | author=Hayflick JS, Stine J, Fox R, "et al." |title=Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22207–14 |year= 1997 |pmid= 9268366 |doi=
*cite journal | author=Serrador JM, Alonso-Lebrero JL, del Pozo MA, "et al." |title=Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization. |journal=J. Cell Biol. |volume=138 |issue= 6 |pages= 1409–23 |year= 1997 |pmid= 9298994 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bernstein CN, Sargent M, Gallatin WM |title=Beta2 integrin/ICAM expression in Crohn's disease. |journal=Clin. Immunol. Immunopathol. |volume=86 |issue= 2 |pages= 147–60 |year= 1998 |pmid= 9473377 |doi=

External links

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