- ITGA5
Integrin, alpha 5 (fibronectin receptor, alpha polypeptide), also known as ITGA5, is a human
gene .PBB_Summary
section_title =
summary_text = The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [cite web | title = Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3678| accessdate = ]ee also
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Cluster of differentiation
*Integrin References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ruoslahti E |title=Integrin signaling and matrix assembly. |journal=Tumour Biol. |volume=17 |issue= 2 |pages= 117–24 |year= 1996 |pmid= 8658014 |doi=
*cite journal | author=Coulombel L, Auffray I, Gaugler MH, Rosemblatt M |title=Expression and function of integrins on hematopoietic progenitor cells. |journal=Acta Haematol. |volume=97 |issue= 1-2 |pages= 13–21 |year= 1997 |pmid= 8980606 |doi=
*cite journal | author=Porter JC, Hogg N |title=Integrins take partners: cross-talk between integrins and other membrane receptors. |journal=Trends Cell Biol. |volume=8 |issue= 10 |pages= 390–6 |year= 1999 |pmid= 9789327 |doi=
*cite journal | author=Evans JP |title=Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. |journal=Bioessays |volume=23 |issue= 7 |pages= 628–39 |year= 2001 |pmid= 11462216 |doi= 10.1002/bies.1088External links
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PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
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