MLLT4

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4, also known as MLLT4, is a human gene.

PBB_Summary
section_title =
summary_text = AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998). [supplied by OMIM] cite web | title = Entrez Gene: MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4301| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takai Y, Nakanishi H |title=Nectin and afadin: novel organizers of intercellular junctions. |journal=J. Cell. Sci. |volume=116 |issue= Pt 1 |pages= 17–27 |year= 2003 |pmid= 12456712 |doi=
*cite journal | author=Prasad R, Gu Y, Alder H, "et al." |title=Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. |journal=Cancer Res. |volume=53 |issue= 23 |pages= 5624–8 |year= 1994 |pmid= 8242616 |doi=
*cite journal | author=Saha V, Lillington DM, Shelling AN, "et al." |title=AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer. |journal=Genes Chromosomes Cancer |volume=14 |issue= 3 |pages= 220–2 |year= 1996 |pmid= 8589040 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Mandai K, Nakanishi H, Satoh A, "et al." |title=Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. |journal=J. Cell Biol. |volume=139 |issue= 2 |pages= 517–28 |year= 1997 |pmid= 9334353 |doi=
*cite journal | author=Joh T, Yamamoto K, Kagami Y, "et al." |title=Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus. |journal=Oncogene |volume=15 |issue= 14 |pages= 1681–7 |year= 1997 |pmid= 9349501 |doi= 10.1038/sj.onc.1201332
*cite journal | author=Saito S, Matsushima M, Shirahama S, "et al." |title=Complete genomic structure DNA polymorphisms, and alternative splicing of the human AF-6 gene. |journal=DNA Res. |volume=5 |issue= 2 |pages= 115–20 |year= 1998 |pmid= 9679199 |doi=
*cite journal | author=Hock B, Böhme B, Karn T, "et al." |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–84 |year= 1998 |pmid= 9707552 |doi=
*cite journal | author=Taya S, Yamamoto T, Kano K, "et al." |title=The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. |journal=J. Cell Biol. |volume=142 |issue= 4 |pages= 1053–62 |year= 1998 |pmid= 9722616 |doi=
*cite journal | author=Mandai K, Nakanishi H, Satoh A, "et al." |title=Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. |journal=J. Cell Biol. |volume=144 |issue= 5 |pages= 1001–17 |year= 1999 |pmid= 10085297 |doi=
*cite journal | author=Linnemann T, Geyer M, Jaitner BK, "et al." |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556–62 |year= 1999 |pmid= 10224125 |doi=
*cite journal | author=Takahashi K, Nakanishi H, Miyahara M, "et al." |title=Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. |journal=J. Cell Biol. |volume=145 |issue= 3 |pages= 539–49 |year= 1999 |pmid= 10225955 |doi=
*cite journal | author=Yamamoto T, Harada N, Kawano Y, "et al." |title=In vivo interaction of AF-6 with activated Ras and ZO-1. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 1 |pages= 103–7 |year= 1999 |pmid= 10334923 |doi= 10.1006/bbrc.1999.0731
*cite journal | author=Minaguchi T, Matsushima M, Saito S, "et al." |title=Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer. |journal=DNA Res. |volume=6 |issue= 2 |pages= 131–6 |year= 1999 |pmid= 10382971 |doi=
*cite journal | author=Quilliam LA, Castro AF, Rogers-Graham KS, "et al." |title=M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23850–7 |year= 1999 |pmid= 10446149 |doi=
*cite journal | author=Kawabe H, Hata Y, Takeuchi M, "et al." |title=nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30914–8 |year= 1999 |pmid= 10521485 |doi=
*cite journal | author=Shao H, Kadono-Okuda K, Finlin BS, Andres DA |title=Biochemical characterization of the Ras-related GTPases Rit and Rin. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 207–19 |year= 1999 |pmid= 10545207 |doi= 10.1006/abbi.1999.1448
*cite journal | author=Asakura T, Nakanishi H, Sakisaka T, "et al." |title=Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells. |journal=Genes Cells |volume=4 |issue= 10 |pages= 573–81 |year= 2000 |pmid= 10583506 |doi=
*cite journal | author=Miyahara M, Nakanishi H, Takahashi K, "et al." |title=Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 613–8 |year= 2000 |pmid= 10617658 |doi=
*cite journal | author=Bouchard MJ, Dong Y, McDermott BM, "et al." |title=Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions. |journal=Mol. Cell. Biol. |volume=20 |issue= 8 |pages= 2865–73 |year= 2000 |pmid= 10733589 |doi=

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