CFLAR

CASP8 and FADD-like apoptosis regulator
Rendering based on PDB 3H11.
Available structures PDB 3H11, 3H13
Identifiers
Symbols	CFLAR; CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS
External IDs	OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR Gene
Gene Ontology Molecular function • cysteine-type endopeptidase activity • protein binding Cellular component • cytoplasm • CD95 death-inducing signaling complex Biological process • proteolysis • anti-apoptosis • induction of apoptosis by extracellular signals • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of caspase activity • interspecies interaction between organisms Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8837	12633
Ensembl	ENSG00000003402	ENSMUSG00000026031
UniProt	O15519	Q812G4
RefSeq (mRNA)	NM_001127183.2	NM_009805
RefSeq (protein)	NP_001120655.1	NP_033935
Location (UCSC)	Chr 2: 201.98 – 202.03 Mb	Chr 1: 58.77 – 58.82 Mb
PubMed search	[1]	[2]

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[1][2] Also called FLICE-like inhibitory protein (FLIP).

References

1. ^ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847. 
2. ^ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. 

Further reading

• Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041. 
• Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.". Expert Opin. Ther. Targets 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226.