- BCL3
B-cell CLL/lymphoma 3, also known as BCL3, is a human
gene .This gene is a proto-
oncogene candidate. It is identified by its translocation into theimmunoglobulin alpha-locus in some cases ofB-cell leukemia . The protein encoded by this gene contains sevenankyrin repeat s, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.cite web | title = Entrez Gene: BCL3 B-cell CLL/lymphoma 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=602| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Franzoso G, Bours V, Park S, "et al." |title=The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition. |journal=Nature |volume=359 |issue= 6393 |pages= 339–42 |year= 1992 |pmid= 1406939 |doi= 10.1038/359339a0
*cite journal | author=Wulczyn FG, Naumann M, Scheidereit C |title=Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. |journal=Nature |volume=358 |issue= 6387 |pages= 597–9 |year= 1992 |pmid= 1501714 |doi= 10.1038/358597a0
*cite journal | author=Bhatia K, Huppi K, McKeithan T, "et al." |title=Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes. |journal=Oncogene |volume=6 |issue= 9 |pages= 1569–73 |year= 1991 |pmid= 1923524 |doi=
*cite journal | author=Mills FC, Brooker JS, Camerini-Otero RD |title=Sequences of human immunoglobulin switch regions: implications for recombination and transcription. |journal=Nucleic Acids Res. |volume=18 |issue= 24 |pages= 7305–16 |year= 1991 |pmid= 2124350 |doi=
*cite journal | author=Ohno H, Takimoto G, McKeithan TW |title=The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. |journal=Cell |volume=60 |issue= 6 |pages= 991–7 |year= 1990 |pmid= 2180580 |doi=
*cite journal | author=Crossen PE, Kennedy MA, Heaton DC, Morrison MJ |title=Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region. |journal=Genes Chromosomes Cancer |volume=8 |issue= 1 |pages= 60–2 |year= 1993 |pmid= 7691160 |doi=
*cite journal | author=McKeithan TW, Ohno H, Dickstein J, Hume E |title=Genomic structure of the candidate proto-oncogene BCL3. |journal=Genomics |volume=24 |issue= 1 |pages= 120–6 |year= 1995 |pmid= 7896265 |doi= 10.1006/geno.1994.1588
*cite journal | author=Zhang Q, Didonato JA, Karin M, McKeithan TW |title=BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 6 |pages= 3915–26 |year= 1994 |pmid= 8196632 |doi=
*cite journal | author=Fujita T, Nolan GP, Liou HC, "et al." |title=The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. |journal=Genes Dev. |volume=7 |issue= 7B |pages= 1354–63 |year= 1993 |pmid= 8330739 |doi=
*cite journal | author=Naumann M, Wulczyn FG, Scheidereit C |title=The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B. |journal=EMBO J. |volume=12 |issue= 1 |pages= 213–22 |year= 1993 |pmid= 8428580 |doi=
*cite journal | author=Bours V, Franzoso G, Azarenko V, "et al." |title=The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. |journal=Cell |volume=72 |issue= 5 |pages= 729–39 |year= 1993 |pmid= 8453667 |doi=
*cite journal | author=Nolan GP, Fujita T, Bhatia K, "et al." |title=The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. |journal=Mol. Cell. Biol. |volume=13 |issue= 6 |pages= 3557–66 |year= 1993 |pmid= 8497270 |doi=
*cite journal | author=Watanabe N, Iwamura T, Shinoda T, Fujita T |title=Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation. |journal=EMBO J. |volume=16 |issue= 12 |pages= 3609–20 |year= 1997 |pmid= 9218802 |doi= 10.1093/emboj/16.12.3609
*cite journal | author=Bundy DL, McKeithan TW |title=Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33132–9 |year= 1998 |pmid= 9407099 |doi=
*cite journal | author=Weyrich AS, Dixon DA, Pabla R, "et al." |title=Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 10 |pages= 5556–61 |year= 1998 |pmid= 9576921 |doi=
*cite journal | author=Na SY, Choi HS, Kim JW, "et al." |title=Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 30933–8 |year= 1998 |pmid= 9812988 |doi=
*cite journal | author=Dechend R, Hirano F, Lehmann K, "et al." |title=The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. |journal=Oncogene |volume=18 |issue= 22 |pages= 3316–23 |year= 1999 |pmid= 10362352 |doi= 10.1038/sj.onc.1202717
*cite journal | author=Na SY, Choi JE, Kim HJ, "et al." |title=Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28491–6 |year= 1999 |pmid= 10497212 |doi=
*cite journal | author=Neumann M, Fries H, Scheicher C, "et al." |title=Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells. |journal=Blood |volume=95 |issue= 1 |pages= 277–85 |year= 2000 |pmid= 10607713 |doi=
*cite journal | author=Brasier AR, Lu M, Hai T, "et al." |title=NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32080–93 |year= 2001 |pmid= 11387332 |doi= 10.1074/jbc.M102949200PBB_Controls
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