MAP3K11

MAP3K11

Mitogen-activated protein kinase kinase kinase 11, also known as MAP3K11, is a human gene.

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summary_text = The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.cite web | title = Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4296| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=van de Bovenkamp M, Nottet HS, Pereira CF |title=Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia. |journal=Eur. J. Clin. Invest. |volume=32 |issue= 8 |pages= 619–27 |year= 2003 |pmid= 12190962 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Ing YL, Leung IW, Heng HH, "et al." |title=MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. |journal=Oncogene |volume=9 |issue= 6 |pages= 1745–50 |year= 1994 |pmid= 8183572 |doi=
*cite journal | author=Gallo KA, Mark MR, Scadden DT, "et al." |title=Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. |journal=J. Biol. Chem. |volume=269 |issue= 21 |pages= 15092–100 |year= 1994 |pmid= 8195146 |doi=
*cite journal | author=Smith CM, Ma NS, Nowak NJ, "et al." |title=A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. |journal=Genome Res. |volume=7 |issue= 8 |pages= 835–42 |year= 1997 |pmid= 9267807 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nagata K, Puls A, Futter C, "et al." |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149–58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149
*cite journal | author=Tanaka S, Hanafusa H |title=Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1281–4 |year= 1998 |pmid= 9430657 |doi=
*cite journal | author=Leung IW, Lassam N |title=Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32408–15 |year= 1999 |pmid= 9829970 |doi=
*cite journal | author=Merritt SE, Mata M, Nihalani D, "et al." |title=The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10195–202 |year= 1999 |pmid= 10187804 |doi=
*cite journal | author=Yasuda J, Whitmarsh AJ, Cavanagh J, "et al." |title=The JIP group of mitogen-activated protein kinase scaffold proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7245–54 |year= 2000 |pmid= 10490659 |doi=
*cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=
*cite journal | author=Hehner SP, Hofmann TG, Ushmorov A, "et al." |title=Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2556–68 |year= 2000 |pmid= 10713178 |doi=
*cite journal | author=Böck BC, Vacratsis PO, Qamirani E, Gallo KA |title=Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14231–41 |year= 2000 |pmid= 10799501 |doi=
*cite journal | author=Leung IW, Lassam N |title=The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 3 |pages= 1961–7 |year= 2001 |pmid= 11053428 |doi= 10.1074/jbc.M004092200
*cite journal | author=Svensson AC, Raudsepp T, Larsson C, "et al." |title=Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 1-2 |pages= 89–96 |year= 2001 |pmid= 11306803 |doi=
*cite journal | author=Zhang H, Gallo KA |title=Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 45598–603 |year= 2002 |pmid= 11590155 |doi= 10.1074/jbc.M107176200
*cite journal | author=Lambert JM, Karnoub AE, Graves LM, "et al." |title=Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4770–7 |year= 2002 |pmid= 11713255 |doi= 10.1074/jbc.M109379200
*cite journal | author=Chadee DN, Yuasa T, Kyriakis JM |title=Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 737–49 |year= 2002 |pmid= 11784851 |doi=
*cite journal | author=Vacratsis PO, Phinney BS, Gage DA, Gallo KA |title=Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping. |journal=Biochemistry |volume=41 |issue= 17 |pages= 5613–24 |year= 2002 |pmid= 11969422 |doi=

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