P2RY2

Purinergic receptor P2Y, G-protein coupled, 2
Identifiers
Symbols	P2RY2; HP2U; MGC20088; MGC40010; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R
External IDs	OMIM: 600041 MGI: 105107 HomoloGene: 1927 GeneCards: P2RY2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • ATP binding • A1 adenosine receptor binding • purinergic nucleotide receptor activity, G-protein coupled • UTP-activated nucleotide receptor activity Cellular component • mitochondrion • lysosome • early endosome • plasma membrane • plasma membrane • integral to plasma membrane • basolateral plasma membrane • apical plasma membrane Biological process • cellular ion homeostasis • activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger • elevation of cytosolic calcium ion concentration • aging • embryo development • positive regulation of neuron projection development • positive regulation of smooth muscle cell migration • sensory perception of pain • negative regulation of ossification • positive regulation of prostaglandin secretion • positive regulation of chemokine production • wound healing • regulation of vasodilation • positive regulation of penile erection • response to growth factor stimulus • cellular response to interleukin-1 • cellular response to purine-containing compound Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5029	18442
Ensembl	ENSG00000175591	ENSMUSG00000032860
UniProt	P41231	Q3U185
RefSeq (mRNA)	NM_002564.2	NM_008773.3
RefSeq (protein)	NP_002555.2	NP_032799.2
Location (UCSC)	Chr 11: 72.93 – 72.95 Mb	Chr 7: 108.15 – 108.16 Mb
PubMed search	[1]	[2]

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.^[1][2]

The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[3]

See also

• P2Y receptor
• Denufosol, a P2Y₂ agonist

References

1. ^ Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA 91 (8): 3275–9. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43559. 
2. ^ Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708. 
3. ^ "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5029. 

External links

• "P2Y Receptors: P2Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2394. 

Further reading

• Tokuyama Y, Hara M, Jones EM, et al. (1995). "Cloning of rat and mouse P2Y purinoceptors.". Biochem. Biophys. Res. Commun. 211 (1): 211–8. doi:10.1006/bbrc.1995.1798. PMID 7779087. 
• Parr CE, Sullivan DM, Paradiso AM, et al. (1995). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 13067. doi:10.1073/pnas.91.26.13067. PMC 45582. PMID 7809171. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45582. 
• Erb L, Lustig KD, Sullivan DM, et al. (1993). "Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10449–53. doi:10.1073/pnas.90.22.10449. PMC 47794. PMID 8248130. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47794. 
• Dasari VR, Sandhu AK, Mills DC, et al. (1996). "Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1.". Somat. Cell Mol. Genet. 22 (1): 75–9. doi:10.1007/BF02374378. PMID 8643996. 
• Sullivan DM, Erb L, Anglade E, et al. (1997). "Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells.". J. Neurosci. Res. 49 (1): 43–52. doi:10.1002/(SICI)1097-4547(19970701)49:1<43::AID-JNR5>3.0.CO;2-D. PMID 9211988. 
• Bogdanov Y, Rubino A, Burnstock G (1998). "Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart.". Life Sci. 62 (8): 697–703. doi:10.1016/S0024-3205(97)01168-5. PMID 9489506. 
• Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). "Distribution of P2Y receptor subtypes on haematopoietic cells.". Br. J. Pharmacol. 123 (5): 789–94. doi:10.1038/sj.bjp.0701665. PMC 1565225. PMID 9535005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1565225. 
• Tai CJ, Kang SK, Cheng KW, et al. (2000). "Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells.". J. Clin. Endocrinol. Metab. 85 (4): 1591–7. doi:10.1210/jc.85.4.1591. PMID 10770202. 
• Erb L, Liu J, Ockerhausen J, et al. (2001). "An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction.". J. Cell Biol. 153 (3): 491–501. doi:10.1083/jcb.153.3.491. PMC 2190579. PMID 11331301. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190579. 
• Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1-3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858. 
• Schafer R, Sedehizade F, Welte T, Reiser G (2003). "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958. 
• Seye CI, Yu N, Jain R, et al. (2003). "The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells.". J. Biol. Chem. 278 (27): 24960–5. doi:10.1074/jbc.M301439200. PMID 12714597. 
• Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128. 
• Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424. 
• Meshki J, Tuluc F, Bredetean O, et al. (2004). "Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.". Am. J. Physiol., Cell Physiol. 286 (2): C264–71. doi:10.1152/ajpcell.00287.2003. PMID 14613890. 
• Haserück N, Erl W, Pandey D, et al. (2004). "The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors.". Blood 103 (7): 2585–92. doi:10.1182/blood-2003-04-1127. PMID 14645014. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)