ADAM12

ADAM metallopeptidase domain 12 (meltrin alpha), also known as ADAM12, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.cite web | title = Entrez Gene: ADAM12 ADAM metallopeptidase domain 12 (meltrin alpha)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8038| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yagami-Hiromasa T, Sato T, Kurisaki T, "et al." |title=A metalloprotease-disintegrin participating in myoblast fusion. |journal=Nature |volume=377 |issue= 6550 |pages= 652–6 |year= 1995 |pmid= 7566181 |doi= 10.1038/377652a0
*cite journal | author=Gilpin BJ, Loechel F, Mattei MG, "et al." |title=A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 157–66 |year= 1998 |pmid= 9417060 |doi=
*cite journal | author=Loechel F, Gilpin BJ, Engvall E, "et al." |title=Human ADAM 12 (meltrin alpha) is an active metalloprotease. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16993–7 |year= 1998 |pmid= 9642263 |doi=
*cite journal | author=Howard L, Nelson KK, Maciewicz RA, Blobel CP |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31693–9 |year= 1999 |pmid= 10531379 |doi=
*cite journal | author=Galliano MF, Huet C, Frygelius J, "et al." |title=Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13933–9 |year= 2000 |pmid= 10788519 |doi=
*cite journal | author=Iba K, Albrechtsen R, Gilpin B, "et al." |title=The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1143–56 |year= 2000 |pmid= 10831617 |doi=
*cite journal | author=Shi Z, Xu W, Loechel F, "et al." |title=ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18574–80 |year= 2000 |pmid= 10849447 |doi= 10.1074/jbc.M002172200
*cite journal | author=Eto K, Puzon-McLaughlin W, Sheppard D, "et al." |title=RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34922–30 |year= 2001 |pmid= 10944520 |doi= 10.1074/jbc.M001953200
*cite journal | author=Loechel F, Fox JW, Murphy G, "et al." |title=ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 511–5 |year= 2001 |pmid= 11095942 |doi= 10.1006/bbrc.2000.3835
*cite journal | author=Suzuki A, Kadota N, Hara T, "et al." |title=Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src. |journal=Oncogene |volume=19 |issue= 51 |pages= 5842–50 |year= 2000 |pmid= 11127814 |doi=
*cite journal | author=Kang Q, Cao Y, Zolkiewska A |title=Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates phosphatidylinositol 3-kinase in C2C12 cells. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24466–72 |year= 2001 |pmid= 11313349 |doi= 10.1074/jbc.M101162200
*cite journal | author=Kawaguchi N, Xu X, Tajima R, "et al." |title=ADAM 12 protease induces adipogenesis in transgenic mice. |journal=Am. J. Pathol. |volume=160 |issue= 5 |pages= 1895–903 |year= 2002 |pmid= 12000741 |doi=
*cite journal | author=Cao Y, Kang Q, Zhao Z, Zolkiewska A |title=Intracellular processing of metalloprotease disintegrin ADAM12. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26403–11 |year= 2002 |pmid= 12000744 |doi= 10.1074/jbc.M110814200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Abram CL, Seals DF, Pass I, "et al." |title=The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16844–51 |year= 2003 |pmid= 12615925 |doi= 10.1074/jbc.M300267200
*cite journal | author=Le Pabic H, Bonnier D, Wewer UM, "et al." |title=ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling. |journal=Hepatology |volume=37 |issue= 5 |pages= 1056–66 |year= 2003 |pmid= 12717386 |doi= 10.1053/jhep.2003.50205
*cite journal | author=Kawaguchi N, Sundberg C, Kveiborg M, "et al." |title=ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. |journal=J. Cell. Sci. |volume=116 |issue= Pt 19 |pages= 3893–904 |year= 2004 |pmid= 12915587 |doi= 10.1242/jcs.00699
*cite journal | author=Mori S, Tanaka M, Nanba D, "et al." |title=PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 46029–34 |year= 2003 |pmid= 12952982 |doi= 10.1074/jbc.M306393200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Laigaard J, Sørensen T, Fröhlich C, "et al." |title=ADAM12: a novel first-trimester maternal serum marker for Down syndrome. |journal=Prenat. Diagn. |volume=23 |issue= 13 |pages= 1086–91 |year= 2004 |pmid= 14691998 |doi= 10.1002/pd.762

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