Hypertensive nephropathy

Hypertensive nephropathy
Classification and external resources
ICD-10	I12
ICD-9	403

Hypertensive nephropathy (or "hypertensive nephrosclerosis", or "Hypertensive renal disease") is a medical condition referring to damage to the kidney due to chronic high blood pressure.

It should be distinguished from "renovascular hypertension" (I15.0), which is a form of secondary hypertension.

In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the wall of small arteries and arterioles, producing the thickening of their walls and the narrowing of the lumina — hyaline arteriolosclerosis. Consequent ischemia will produce tubular atrophy, interstitial fibrosis, glomerular alterations (smaller glomeruli with different degrees of hyalinization - from mild to sclerosis of glomeruli) and periglomerular fibrosis. In advanced stages, renal failure will occur. Functional nephrons have dilated tubules, often with hyaline casts in the lumens. Additional complications often associated with hypertensive nephropathy include glomerular damage resulting in proteinuria and hematuria.

See also

• Nephropathy

External links

• Photo at Atlas of Pathology
• Tylicki L, Rutkowski B (2003). "[Hypertensive nephropathy: pathogenesis, diagnosis and treatment]" (in Polish). Pol. Merkur. Lekarski 14 (80): 168–73. PMID 12728683. 
• Luft FC (October 2000). "Hypertensive nephrosclerosis-a cause of end-stage renal disease?". Nephrol Dial Transplant. 15 (10): 1515–7. doi:10.1093/ndt/15.10.1515. PMID 11007815. http://ndt.oxfordjournals.org/cgi/content/full/15/10/1515.