Bradykinin receptor B1

Bradykinin receptor B1

Bradykinin receptor B1, also known as BDKRB1, is a human gene.

Bradykinin, a 9 amino acid peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G protein-coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.cite web | title = Entrez Gene: BDKRB1 bradykinin receptor B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=623| accessdate = ]

ee also

* Bradykinin receptor

References

Further reading

*cite journal | author=Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A |title=A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4849-56 |year= 2007 |pmid= 17878384 |doi= PBB_Further_reading
citations =
*cite journal | author=Calixto JB, Medeiros R, Fernandes ES, "et al." |title=Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. |journal=Br. J. Pharmacol. |volume=143 |issue= 7 |pages= 803–18 |year= 2005 |pmid= 15520046 |doi= 10.1038/sj.bjp.0706012
*cite journal | author=Menke JG, Borkowski JA, Bierilo KK, "et al." |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583–6 |year= 1994 |pmid= 8063797 |doi=
*cite journal | author=Yang X, Polgar P |title=Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 3 |pages= 718–25 |year= 1996 |pmid= 8651911 |doi= 10.1006/bbrc.1996.0810
*cite journal | author=Bachvarov DR, Hess JF, Menke JG, "et al." |title=Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). |journal=Genomics |volume=33 |issue= 3 |pages= 374–81 |year= 1996 |pmid= 8660997 |doi= 10.1006/geno.1996.0213
*cite journal | author=Chai KX, Ni A, Wang D, "et al." |title=Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. |journal=Genomics |volume=31 |issue= 1 |pages= 51–7 |year= 1996 |pmid= 8808279 |doi= 10.1006/geno.1996.0008
*cite journal | author=Leeb T, Mathis SA, Leeb-Lundberg LM |title=The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists. |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 311–7 |year= 1997 |pmid= 8995263 |doi=
*cite journal | author=Blaukat A, Herzer K, Schroeder C, "et al." |title=Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation. |journal=Biochemistry |volume=38 |issue= 4 |pages= 1300–9 |year= 1999 |pmid= 9930991 |doi= 10.1021/bi981727r
*cite journal | author=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239–44 |year= 1999 |pmid= 10188626 |doi=
*cite journal | author=Zhou X, Prado GN, Chai M, "et al." |title=Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region. |journal=Mol. Cell Biol. Res. Commun. |volume=1 |issue= 1 |pages= 29–35 |year= 2000 |pmid= 10329474 |doi= 10.1006/mcbr.1999.0105
*cite journal | author=Jones C, Phillips E, Davis C, "et al." |title=Molecular characterisation of cloned bradykinin B1 receptors from rat and human. |journal=Eur. J. Pharmacol. |volume=374 |issue= 3 |pages= 423–33 |year= 1999 |pmid= 10422787 |doi=
*cite journal | author=Sjuve R, Boels PJ, Uvelius B, Arner A |title=Up-regulation of bradykinin response in rat and human bladder smooth muscle. |journal=J. Urol. |volume=164 |issue= 5 |pages= 1757–63 |year= 2000 |pmid= 11025765 |doi=
*cite journal | author=Sawant S, Snyman C, Bhoola K |title=Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms. |journal=Int. Immunopharmacol. |volume=1 |issue= 12 |pages= 2063–80 |year= 2002 |pmid= 11710536 |doi=
*cite journal | author=Ignjatovic T, Tan F, Brovkovych V, "et al." |title=Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16847–52 |year= 2002 |pmid= 11880373 |doi= 10.1074/jbc.M200355200
*cite journal | author=Newton R, Eddleston J, Haddad el-B, "et al." |title=Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone. |journal=Eur. J. Pharmacol. |volume=441 |issue= 3 |pages= 193–202 |year= 2002 |pmid= 12063092 |doi=
*cite journal | author=Kang DS, Leeb-Lundberg LM |title=Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity. |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 281–8 |year= 2002 |pmid= 12130679 |doi=
*cite journal | author=Christiansen SC, Eddleston J, Woessner KM, "et al." |title=Up-regulation of functional kinin B1 receptors in allergic airway inflammation. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 2054–60 |year= 2002 |pmid= 12165532 |doi=
*cite journal | author=Lamb ME, Zhang C, Shea T, "et al." |title=Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14340–7 |year= 2003 |pmid= 12450400 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM |title=Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22102–7 |year= 2004 |pmid= 15033977 |doi= 10.1074/jbc.M402572200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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