Interleukin 10 receptor, alpha subunit

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.

IL10RA has also recently been designated CDW210A (cluster of differentiation W210A).

PBB_Summary
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summary_text = The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.cite web | title = Entrez Gene: IL10RA interleukin 10 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3587| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Donnelly RP, Dickensheets H, Finbloom DS |title=The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 6 |pages= 563–73 |year= 1999 |pmid= 10433356 |doi= 10.1089/107999099313695
*cite journal | author=Carson WE, Lindemann MJ, Baiocchi R, "et al." |title=The functional characterization of interleukin-10 receptor expression on human natural killer cells. |journal=Blood |volume=85 |issue= 12 |pages= 3577–85 |year= 1995 |pmid= 7540068 |doi=
*cite journal | author=Ho AS, Wei SH, Mui AL, "et al." |title=Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5043–53 |year= 1995 |pmid= 7544437 |doi=
*cite journal | author=Tan JC, Braun S, Rong H, "et al." |title=Characterization of recombinant extracellular domain of human interleukin-10 receptor. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12906–11 |year= 1995 |pmid= 7759550 |doi=
*cite journal | author=Taniyama T, Takai S, Miyazaki E, "et al." |title=The human interleukin-10 receptor gene maps to chromosome 11q23.3. |journal=Hum. Genet. |volume=95 |issue= 1 |pages= 99–101 |year= 1995 |pmid= 7814035 |doi=
*cite journal | author=Liu Y, Wei SH, Ho AS, "et al." |title=Expression cloning and characterization of a human IL-10 receptor. |journal=J. Immunol. |volume=152 |issue= 4 |pages= 1821–9 |year= 1994 |pmid= 8120391 |doi=
*cite journal | author=Ho AS, Liu Y, Khan TA, "et al." |title=A receptor for interleukin 10 is related to interferon receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11267–71 |year= 1994 |pmid= 8248239 |doi=
*cite journal | author=Tan JC, Indelicato SR, Narula SK, "et al." |title=Characterization of interleukin-10 receptors on human and mouse cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 21053–9 |year= 1993 |pmid= 8407942 |doi=
*cite journal | author=Lai CF, Ripperger J, Morella KK, "et al." |title=Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 13968–75 |year= 1996 |pmid= 8662928 |doi=
*cite journal | author=Zdanov A, Schalk-Hihi C, Wlodawer A |title=Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor. |journal=Protein Sci. |volume=5 |issue= 10 |pages= 1955–62 |year= 1997 |pmid= 8897595 |doi=
*cite journal | author=Kotenko SV, Krause CD, Izotova LS, "et al." |title=Identification and functional characterization of a second chain of the interleukin-10 receptor complex. |journal=EMBO J. |volume=16 |issue= 19 |pages= 5894–903 |year= 1997 |pmid= 9312047 |doi= 10.1093/emboj/16.19.5894
*cite journal | author=Hoover DM, Schalk-Hihi C, Chou CC, "et al." |title=Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization. |journal=Eur. J. Biochem. |volume=262 |issue= 1 |pages= 134–41 |year= 1999 |pmid= 10231374 |doi=
*cite journal | author=Müschen A, Mirmohammadsadegh A, Jarzebska-Deussen B, "et al." |title=Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. |journal=Inflamm. Res. |volume=48 |issue= 10 |pages= 539–43 |year= 1999 |pmid= 10563471 |doi=
*cite journal | author=Corinti S, Albanesi C, la Sala A, "et al." |title=Regulatory activity of autocrine IL-10 on dendritic cell functions. |journal=J. Immunol. |volume=166 |issue= 7 |pages= 4312–8 |year= 2001 |pmid= 11254683 |doi=
*cite journal | author=Josephson K, Logsdon NJ, Walter MR |title=Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. |journal=Immunity |volume=15 |issue= 1 |pages= 35–46 |year= 2001 |pmid= 11485736 |doi=
*cite journal | author=Crepaldi L, Gasperini S, Lapinet JA, "et al." |title=Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10. |journal=J. Immunol. |volume=167 |issue= 4 |pages= 2312–22 |year= 2001 |pmid= 11490020 |doi=
*cite journal | author=Zhou JH, Broussard SR, Strle K, "et al." |title=IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase. |journal=J. Immunol. |volume=167 |issue= 8 |pages= 4436–42 |year= 2001 |pmid= 11591769 |doi=
*cite journal | author=Josephson K, McPherson DT, Walter MR |title=Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 12 |pages= 1908–11 |year= 2002 |pmid= 11717514 |doi=
*cite journal | author=Wolk K, Kunz S, Asadullah K, Sabat R |title=Cutting edge: immune cells as sources and targets of the IL-10 family members? |journal=J. Immunol. |volume=168 |issue= 11 |pages= 5397–402 |year= 2002 |pmid= 12023331 |doi=

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