LIG1

Ligase I, DNA, ATP-dependent, also known as LIG1, is a human gene.

PBB_Summary
section_title =
summary_text = LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.cite web | title = Entrez Gene: LIG1 ligase I, DNA, ATP-dependent| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3978| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Leonhardt H, Cardoso MC |title=Targeting and association of proteins with functional domains in the nucleus: the insoluble solution. |journal=Int. Rev. Cytol. |volume=162B |issue= |pages= 303–35 |year= 1996 |pmid= 8557490 |doi=
*cite journal | author=Tomkinson AE, Mackey ZB |title=Structure and function of mammalian DNA ligases. |journal=Mutat. Res. |volume=407 |issue= 1 |pages= 1–9 |year= 1998 |pmid= 9539976 |doi=
*cite journal | author=Perrigot M, Pierrot-Deseilligny E, Bussel B, Held JP |title= [Paralysis following Dimer X radiculography] |journal=La Nouvelle presse médicale |volume=5 |issue= 17 |pages= 1120–2 |year= 1976 |pmid= 934827 |doi=
*cite journal | author=Webster AD, Barnes DE, Arlett CF, "et al." |title=Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene. |journal=Lancet |volume=339 |issue= 8808 |pages= 1508–9 |year= 1992 |pmid= 1351188 |doi=
*cite journal | author=Barnes DE, Tomkinson AE, Lehmann AR, "et al." |title=Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents. |journal=Cell |volume=69 |issue= 3 |pages= 495–503 |year= 1992 |pmid= 1581963 |doi=
*cite journal | author=Barnes DE, Kodama K, Tynan K, "et al." |title=Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3. |journal=Genomics |volume=12 |issue= 1 |pages= 164–6 |year= 1992 |pmid= 1733856 |doi=
*cite journal | author=Petrini JH, Huwiler KG, Weaver DT |title=A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7615–9 |year= 1991 |pmid= 1881902 |doi=
*cite journal | author=Lasko DD, Tomkinson AE, Lindahl T |title=Mammalian DNA ligases. Biosynthesis and intracellular localization of DNA ligase I. |journal=J. Biol. Chem. |volume=265 |issue= 21 |pages= 12618–22 |year= 1990 |pmid= 2197279 |doi=
*cite journal | author=Barnes DE, Johnston LH, Kodama K, "et al." |title=Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 17 |pages= 6679–83 |year= 1990 |pmid= 2204063 |doi=
*cite journal | author=Montecucco A, Savini E, Weighardt F, "et al." |title=The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication. |journal=EMBO J. |volume=14 |issue= 21 |pages= 5379–86 |year= 1996 |pmid= 7489727 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Trask B, Fertitta A, Christensen M, "et al." |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133–45 |year= 1993 |pmid= 8432525 |doi=
*cite journal | author=Petrini JH, Walsh ME, DiMare C, "et al." |title=Isolation and characterization of the human MRE11 homologue. |journal=Genomics |volume=29 |issue= 1 |pages= 80–6 |year= 1996 |pmid= 8530104 |doi= 10.1006/geno.1995.1217
*cite journal | author=Bentley D, Selfridge J, Millar JK, "et al." |title=DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. |journal=Nat. Genet. |volume=13 |issue= 4 |pages= 489–91 |year= 1996 |pmid= 8696349 |doi= 10.1038/ng0896-489
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Rossi R, Villa A, Negri C, "et al." |title=The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5745–54 |year= 1999 |pmid= 10523317 |doi= 10.1093/emboj/18.20.5745
*cite journal | author=Matsumoto Y, Kim K, Hurwitz J, "et al." |title=Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33703–8 |year= 1999 |pmid= 10559261 |doi=
*cite journal | author=Vispé S, Satoh MS |title=DNA repair patch-mediated double strand DNA break formation in human cells. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27386–92 |year= 2000 |pmid= 10827190 |doi= 10.1074/jbc.M003126200

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