DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3
PDB rendering based on 2ctt.
Available structures PDB 2CTT, 2DN9
Identifiers
Symbols	DNAJA3; FLJ45758; TID1; hTid-1
External IDs	OMIM: 608382 MGI: 1933786 HomoloGene: 36170 GeneCards: DNAJA3 Gene
Gene Ontology Molecular function • small GTPase regulator activity • interferon-gamma receptor binding • protein binding • ATP binding • transcription factor binding • protein kinase binding • heat shock protein binding • metal ion binding • NF-kappaB binding • unfolded protein binding Cellular component • nucleus • nucleus • cytoplasm • mitochondrial matrix • cytosol • cytosol • actin filament • IkappaB kinase complex • I-kappaB/NF-kappaB complex • mitochondrial nucleoid Biological process • mitochondrial DNA replication • protein folding • protein folding • negative regulation of protein kinase activity • apoptosis • activation of caspase activity • activation-induced cell death of T cells • mitochondrion organization • small GTPase mediated signal transduction • neuromuscular junction development • cell aging • cell death • negative regulation of cell proliferation • response to heat • embryo development • positive regulation of protein ubiquitination • negative regulation of NF-kappaB transcription factor activity • T cell differentiation in thymus • response to interferon-gamma • positive regulation of T cell proliferation • positive regulation of apoptosis • negative regulation of apoptosis • negative regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of caspase activity • protein stabilization • negative regulation of interferon-gamma-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9093	83945
Ensembl	ENSG00000103423	ENSMUSG00000004069
UniProt	Q96EY1	Q3TJA9
RefSeq (mRNA)	NM_001135110.1	NM_023646
RefSeq (protein)	NP_001128582.1	NP_076135
Location (UCSC)	Chr 16: 4.48 – 4.51 Mb	Chr 16: 4.64 – 4.71 Mb
PubMed search	[1]	[2]

DnaJ homolog subfamily A member 3, mitochondrial is a protein that in humans is encoded by the DNAJA3 gene.^[1]

DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ family, see MIM 608375.[supplied by OMIM]^[2]

Interactions

DNAJA3 has been shown to interact with HSPA8,^[3] RAS p21 protein activator 1^[4] and Janus kinase 2.^[3]

References

1. ^ Schilling B, De-Medina T, Syken J, Vidal M, Munger K (August 1998). "A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein". Virology 247 (1): 74–85. doi:10.1006/viro.1998.9220. PMID 9683573. 
2. ^ "Entrez Gene: DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9093. 
3. ^ ^{a b} Sarkar, S; Pollack B P, Lin K T, Kotenko S V, Cook J R, Lewis A, Pestka S (December 2001). "hTid-1, a human DnaJ protein, modulates the interferon signaling pathway". J. Biol. Chem. (United States) 276 (52): 49034–42. doi:10.1074/jbc.M103683200. ISSN 0021-9258. PMID 11679576. 
4. ^ Trentin, G A; Yin X, Tahir S, Lhotak S, Farhang-Fallah J, Li Y, Rozakis-Adcock M (April 2001). "A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. (United States) 276 (16): 13087–95. doi:10.1074/jbc.M009267200. ISSN 0021-9258. PMID 11116152. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Syken J, De-Medina T, Münger K (1999). "TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8499–504. doi:10.1073/pnas.96.15.8499. PMC 17545. PMID 10411904. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17545. 
• Shinohara M, Gasior SL, Bishop DK, Shinohara A (2000). "Tid1/Rdh54 promotes colocalization of rad51 and dmc1 during meiotic recombination". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10814–9. doi:10.1073/pnas.97.20.10814. PMC 27106. PMID 11005857. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27106. 
• Trentin GA, Yin X, Tahir S, et al. (2001). "A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087–95. doi:10.1074/jbc.M009267200. PMID 11116152. 
• Ohtsuka K, Hata M (2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. ISSN 1466-1268. PMC 312896. PMID 11147971. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312896. 
• Sarkar S, Pollack BP, Lin KT, et al. (2002). "hTid-1, a human DnaJ protein, modulates the interferon signaling pathway". J. Biol. Chem. 276 (52): 49034–42. doi:10.1074/jbc.M103683200. PMID 11679576. 
• Yin X, Rozakis-Adcock M (2002). "Genomic organization and expression of the human tumorous imaginal disc (TID1) gene". Gene 278 (1–2): 201–10. doi:10.1016/S0378-1119(01)00720-X. PMID 11707338. 
• Cheng H, Cenciarelli C, Shao Z, et al. (2002). "Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70". Curr. Biol. 11 (22): 1771–5. doi:10.1016/S0960-9822(01)00540-1. PMID 11719219. 
• Cheng H, Cenciarelli C, Tao M, et al. (2002). "HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit". J. Biol. Chem. 277 (23): 20605–10. doi:10.1074/jbc.M201204200. PMID 11927590. 
• Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. PMID 12097419. 
• Sasaki S, Nakamura T, Arakawa H, et al. (2002). "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer". Oncogene 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Syken J, Macian F, Agarwal S, et al. (2003). "TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells". Oncogene 22 (30): 4636–41. doi:10.1038/sj.onc.1206569. PMID 12879007. 
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Lo JF, Hayashi M, Woo-Kim S, et al. (2004). "Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival". Mol. Cell. Biol. 24 (6): 2226–36. doi:10.1128/MCB.24.6.2226-2236.2004. PMC 355836. PMID 14993262. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=355836. 
• Edwards KM, Münger K (2004). "Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant to apoptosis mediated by multiple exogenous stimuli". Oncogene 23 (52): 8419–31. doi:10.1038/sj.onc.1207732. PMID 15156195. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.