GPR35

GPR35 is a G protein-coupled receptor discovered in 1998. cite journal |author=O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR |title=Discovery of three novel G-protein-coupled receptor genes |journal=Genomics |volume=47 |issue=2 |pages=310–3 |year=1998 |pmid=9479505 |doi=10.1006/geno.1998.5095] Hightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.

Ligands

One study has shown that kynurenic acid acts as an endogenous ligand for this receptor. cite journal |author=Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L |title=Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35 |journal=J. Biol. Chem. |volume=281 |issue=31 |pages=22021–8 |year=2006 |pmid=16754668 |doi=10.1074/jbc.M603503200 [http://www.jbc.org/cgi/content/full/281/31/22021 free fulltext] ] Zaprinast, a PDE5A inhibitor, was found to be an agonist for GPR35. cite journal |author=Taniguchi Y, Tonai-Kachi H, Shinjo K |title=Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35 |journal=FEBS Lett. |volume=580 |issue=21 |pages=5003–8 |year=2006 |pmid=16934253 |doi=10.1016/j.febslet.2006.08.015]

Role in pathology

Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome. cite journal |author=Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ |title=Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype |journal=Clin. Genet. |volume=66 |issue=6 |pages=537–44 |year=2004 |pmid=15521982 |doi=10.1111/j.1399-0004.2004.00363.x] In one study GPR35 has been recognised as a potential oncogene in the stomach cancer. cite journal |author=Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K |title=Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells |journal=Cancer Sci. |volume=95 |issue=2 |pages=131–5 |year=2004 |pmid=14965362 |doi=]

References

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = no