CEBPA

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha, also known as CEBPA, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [cite web | title = Entrez Gene: CEBPA CCAAT/enhancer binding protein (C/EBP), alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1050| accessdate = ]

ee also

*Ccaat-enhancer-binding proteins

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sladek FM, Darnell JE |title=Mechanisms of liver-specific gene expression. |journal=Curr. Opin. Genet. Dev. |volume=2 |issue= 2 |pages= 256–9 |year= 1992 |pmid= 1638120 |doi=
*cite journal | author=Marcucci G, Mrózek K, Bloomfield CD |title=Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. |journal=Curr. Opin. Hematol. |volume=12 |issue= 1 |pages= 68–75 |year= 2005 |pmid= 15604894 |doi=
*cite journal | author=Leroy H, Roumier C, Huyghe P, "et al." |title=CEBPA point mutations in hematological malignancies. |journal=Leukemia |volume=19 |issue= 3 |pages= 329–34 |year= 2005 |pmid= 15674366 |doi= 10.1038/sj.leu.2403614

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Calreticulin — PDB rendering based on 1hhn …   Wikipedia

  • Acute myeloid leukemia — DiseaseDisorder infobox Name = Acute myeloid leukemia ICD10 = ICD10|C|92|0|c|81 ICD9 = ICD9|205.0 ICDO = ICDO|9861|3 Caption = Bone marrow aspirate showing acute myeloid leukemia. Arrows indicate Auer rods. OMIM = 602439 MedlinePlus =… …   Wikipedia

  • Cyclin-dependent kinase 2 — CDK2 redirects here. For the airport with the Transport Canada identifier CDK2, see Diavik Airport. Cyclin dependent kinase 2 PDB rendering based on 1aq1 …   Wikipedia

  • Cyclin-dependent kinase 4 — Rendering based on PDB 1LD2 …   Wikipedia

  • CEBP — can stand for: *CEBPA, a human gene that modulates leptin expression *Communication Enabled Business Process …   Wikipedia

  • PRKCH — Protein kinase C, eta, also known as PRKCH, is a human gene.cite web | title = Entrez Gene: PRKCH protein kinase C, eta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5583| accessdate = ] PBB Summary… …   Wikipedia

  • C/EBPs — Dieser Artikel oder Abschnitt bedarf einer Überarbeitung. Näheres ist auf der Diskussionsseite angegeben. Hilf mit, ihn zu verbessern, und entferne anschließend diese Markierung …   Deutsch Wikipedia

  • CCAAT/enhancer-binding-Proteine — Sekundär bis Quartärstruktur Homo /Heterodimer …   Deutsch Wikipedia

  • CCAAT/enhancer-binding proteins — Dieser Artikel oder Abschnitt bedarf einer Überarbeitung. Näheres ist auf der Diskussionsseite angegeben. Hilf mit, ihn zu verbessern, und entferne anschließend diese Markierung …   Deutsch Wikipedia

  • Leucemia mieloide aguda — Células leucémicas …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”