VAV1

Vav 1 oncogene, also known as VAV1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [cite web | title = Entrez Gene: VAV1 vav 1 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7409| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Romero F, Fischer S |title=Structure and function of vav. |journal=Cell. Signal. |volume=8 |issue= 8 |pages= 545–53 |year= 1997 |pmid= 9115846 |doi=
*cite journal | author=Bustelo XR |title=Regulatory and signaling properties of the Vav family. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1461–77 |year= 2000 |pmid= 10669724 |doi=
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Greenway AL, Holloway G, McPhee DA, "et al." |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 12734410 |doi=
*cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 16091223 |doi=
*cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=
*cite journal | author=Katzav S |title=Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. |journal=Cancer Lett. |volume=255 |issue= 2 |pages= 241–54 |year= 2007 |pmid= 17590270 |doi= 10.1016/j.canlet.2007.04.015
*cite journal | author=Bustelo XR, Barbacid M |title=Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. |journal=Science |volume=256 |issue= 5060 |pages= 1196–9 |year= 1992 |pmid= 1375396 |doi=
*cite journal | author=Adams JM, Houston H, Allen J, "et al." |title=The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. |journal=Oncogene |volume=7 |issue= 4 |pages= 611–8 |year= 1992 |pmid= 1565462 |doi=
*cite journal | author=Katzav S, Cleveland JL, Heslop HE, Pulido D |title=Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential. |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 1912–20 |year= 1991 |pmid= 2005887 |doi=
*cite journal | author=Coppola J, Bryant S, Koda T, "et al." |title=Mechanism of activation of the vav protooncogene. |journal=Cell Growth Differ. |volume=2 |issue= 2 |pages= 95–105 |year= 1991 |pmid= 2069873 |doi=
*cite journal | author=Katzav S, Martin-Zanca D, Barbacid M |title=vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. |journal=EMBO J. |volume=8 |issue= 8 |pages= 2283–90 |year= 1989 |pmid= 2477241 |doi=
*cite journal | author=Ramos-Morales F, Romero F, Schweighoffer F, "et al." |title=The proline-rich region of Vav binds to Grb2 and Grb3-3. |journal=Oncogene |volume=11 |issue= 8 |pages= 1665–9 |year= 1995 |pmid= 7478592 |doi=
*cite journal | author=Weng WK, Jarvis L, LeBien TW |title=Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32514–21 |year= 1995 |pmid= 7528218 |doi=
*cite journal | author=Matsuguchi T, Inhorn RC, Carlesso N, "et al." |title=Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. |journal=EMBO J. |volume=14 |issue= 2 |pages= 257–65 |year= 1995 |pmid= 7530656 |doi=
*cite journal | author=Uddin S, Katzav S, White MF, Platanias LC |title=Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7712–6 |year= 1995 |pmid= 7535775 |doi=
*cite journal | author=Machide M, Mano H, Todokoro K |title=Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. |journal=Oncogene |volume=11 |issue= 4 |pages= 619–25 |year= 1995 |pmid= 7651724 |doi=
*cite journal | author=Clevenger CV, Ngo W, Sokol DL, "et al." |title=Vav is necessary for prolactin-stimulated proliferation and is translocated into the nucleus of a T-cell line. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13246–53 |year= 1995 |pmid= 7768923 |doi=
*cite journal | author=Katzav S, Sutherland M, Packham G, "et al." |title=The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32579–85 |year= 1995 |pmid= 7798261 |doi=
*cite journal | author=Ye ZS, Baltimore D |title=Binding of Vav to Grb2 through dimerization of Src homology 3 domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12629–33 |year= 1995 |pmid= 7809090 |doi=

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