Alanine-tRNA ligase

In enzymology, an alanine-tRNA ligase (EC number|6.1.1.7) is an enzyme that catalyzes the chemical reaction

:ATP + L-alanine + tRNAAla $ightleftharpoons$ AMP + diphosphate + L-alanyl-tRNAAla

The 3 substrates of this enzyme are ATP, L-alanine, and tRNA(Ala), whereas its 3 products are AMP, diphosphate, and L-alanyl-tRNA(Ala).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-alanine:tRNAAla ligase (AMP-forming). Other names in common use include alanyl-tRNA synthetase, alanyl-transfer ribonucleate synthetase, alanyl-transfer RNA synthetase, alanyl-transfer ribonucleic acid synthetase, alanine-transfer RNA ligase, alanine transfer RNA synthetase, alanine tRNA synthetase, alanine translase, alanyl-transfer ribonucleate synthase, AlaRS, and Ala-tRNA synthetase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1RIQ, PDB link|1V4P, PDB link|1YFR, PDB link|1YFS, PDB link|1YFT, PDB link|1YGB, and PDB link|2E1B.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9031-71-4."

Gene Ontology (GO) codes