Glutamine-tRNA ligase

Glutamine-tRNA ligase

In enzymology, a glutamine-tRNA ligase (EC number|6.1.1.18) is an enzyme that catalyzes the chemical reaction

:ATP + L-glutamine + tRNAGln ightleftharpoons AMP + diphosphate + L-glutaminyl-tRNAGln

The 3 substrates of this enzyme are ATP, L-glutamine, and tRNA(Gln), whereas its 3 products are AMP, diphosphate, and L-glutaminyl-tRNA(Gln).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamine:tRNAGln ligase (AMP-forming). Other names in common use include glutaminyl-tRNA synthetase, glutaminyl-transfer RNA synthetase, glutaminyl-transfer ribonucleate synthetase, glutamine-tRNA synthetase, glutamine translase, glutamate-tRNA ligase, glutaminyl ribonucleic acid, and GlnRS. This enzyme participates in glutamate metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EUQ, PDB link|1EUY, PDB link|1EXD, PDB link|1GSG, PDB link|1GTR, PDB link|1GTS, PDB link|1NYL, PDB link|1O0B, PDB link|1O0C, PDB link|1QRS, PDB link|1QRT, PDB link|1QRU, PDB link|1QTQ, PDB link|1ZJW, and PDB link|2HZ7.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9075-59-6."

Gene Ontology (GO) codes


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