- Glutamine-tRNA ligase
In
enzymology , a glutamine-tRNA ligase (EC number|6.1.1.18) is anenzyme that catalyzes thechemical reaction :ATP + L-glutamine + tRNAGln AMP + diphosphate + L-glutaminyl-tRNAGln
The 3 substrates of this enzyme are ATP,
L-glutamine , andtRNA(Gln) , whereas its 3 products are AMP,diphosphate , andL-glutaminyl-tRNA(Gln) .This enzyme belongs to the family of
ligase s, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamine:tRNAGln ligase (AMP-forming). Other names in common use include glutaminyl-tRNA synthetase, glutaminyl-transfer RNA synthetase, glutaminyl-transfer ribonucleate synthetase, glutamine-tRNA synthetase, glutamine translase, glutamate-tRNA ligase, glutaminyl ribonucleic acid, and GlnRS. This enzyme participates inglutamate metabolism andaminoacyl-trna biosynthesis .tructural studies
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EUQ, PDB link|1EUY, PDB link|1EXD, PDB link|1GSG, PDB link|1GTR, PDB link|1GTS, PDB link|1NYL, PDB link|1O0B, PDB link|1O0C, PDB link|1QRS, PDB link|1QRT, PDB link|1QRU, PDB link|1QTQ, PDB link|1ZJW, and PDB link|2HZ7.
References
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External links
::"The
CAS registry number for this enzyme class is CAS registry|9075-59-6."Gene Ontology (GO) codes
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