Glutathionylspermidine synthase

Glutathionylspermidine synthase

In enzymology, a glutathionylspermidine synthase (EC number|6.3.1.8) is an enzyme that catalyzes the chemical reaction

:glutathione + spermidine + ATP ightleftharpoons glutathionylspermidine + ADP + phosphate

The 3 substrates of this enzyme are glutathione, spermidine, and ATP, whereas its 3 products are glutathionylspermidine, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule] . This enzyme is also called glutathione:spermidine ligase (ADP-forming). This enzyme participates in glutathione metabolism. It employs one cofactor, magnesium.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2IO7, PDB link|2IO8, PDB link|2IO9, PDB link|2IOA, and PDB link|2IOB.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9077-09-2."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Trypanothione synthase — In enzymology, a trypanothione synthase (EC number|6.3.1.9) is an enzyme that catalyzes the chemical reaction:glutathione + glutathionylspermidine + ATP ightleftharpoons N1,N8 bis(glutathionyl)spermidine + ADP + phosphateThe 3 substrates of this… …   Wikipedia

  • List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia

  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”