Methionine-tRNA ligase

In enzymology, a methionine-tRNA ligase (EC number|6.1.1.10) is an enzyme that catalyzes the chemical reaction

:ATP + L-methionine + tRNAMet $ightleftharpoons$ AMP + diphosphate + L-methionyl-tRNAMet

The 3 substrates of this enzyme are ATP, L-methionine, and tRNA(Met), whereas its 3 products are AMP, diphosphate, and L-methionyl-tRNA(Met).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-methionine:tRNAMet ligase (AMP-forming). Other names in common use include methionyl-tRNA synthetase, methionyl-transfer ribonucleic acid synthetase, methionyl-transfer ribonucleate synthetase, methionyl-transfer RNA synthetase, methionine translase, and MetRS. This enzyme participates in 3 metabolic pathways: methionine metabolism, selenoamino acid metabolism, and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A8H, PDB link|1F4L, PDB link|1MEA, PDB link|1MED, PDB link|1MKH, PDB link|1P7P, PDB link|1PFU, PDB link|1PFV, PDB link|1PFW, PDB link|1PFY, PDB link|1PG0, PDB link|1PG2, PDB link|1QQT, PDB link|1RQG, PDB link|1WOY, PDB link|2CSX, PDB link|2CT8, PDB link|2D54, PDB link|2D5B, PDB link|2DJV, and PDB link|2HSN.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9033-22-1."

Gene Ontology (GO) codes