Proline-tRNA ligase

In enzymology, a proline-tRNA ligase (EC number|6.1.1.15) is an enzyme that catalyzes the chemical reaction

:ATP + L-proline + tRNAPro $ightleftharpoons$ AMP + diphosphate + L-prolyl-tRNAPro

The 3 substrates of this enzyme are ATP, L-proline, and tRNA(Pro), whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA(Pro).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase. This enzyme participates in arginine and proline metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1H4Q, PDB link|1H4S, PDB link|1H4T, PDB link|1HC7, PDB link|1NJ1, PDB link|1NJ2, PDB link|1NJ5, PDB link|1NJ6, PDB link|1NJ8, PDB link|2I4L, PDB link|2I4M, PDB link|2I4N, PDB link|2I4O, PDB link|2J3L, and PDB link|2J3M.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9055-68-9."

Gene Ontology (GO) codes