Tryptophan-tRNA ligase

In enzymology, a tryptophan-tRNA ligase (EC number|6.1.1.2) is an enzyme that catalyzes the chemical reaction

:ATP + L-tryptophan + tRNATrp $ightleftharpoons$ AMP + diphosphate + L-tryptophyl-tRNATrp

The 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA(Trp), whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp.

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1D2R, PDB link|1I6K, PDB link|1I6L, PDB link|1I6M, PDB link|1M83, PDB link|1MAU, PDB link|1MAW, PDB link|1MB2, PDB link|1O5T, PDB link|1R6T, PDB link|1R6U, PDB link|1ULH, PDB link|1YIA, PDB link|1YID, PDB link|2A4M, PDB link|2AKE, PDB link|2AZX, PDB link|2DR2, PDB link|2G36, PDB link|2IP1, and PDB link|2OV4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-44-3."

Gene Ontology (GO) codes