- PRKCG
Protein kinase C, gamma, also known as PRKCG, is a human
gene .PBB_Summary
section_title =
summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [cite web | title = Entrez Gene: PRKCG protein kinase C, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5582| accessdate = ]ee also
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Protein kinase C References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527–40 |year= 2002 |pmid= 11749387 |doi=
*cite journal | author=Slater SJ, Ho C, Stubbs CD |title=The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions. |journal=Chem. Phys. Lipids |volume=116 |issue= 1-2 |pages= 75–91 |year= 2003 |pmid= 12093536 |doi=
*cite journal | author=Saito N, Shirai Y |title=Protein kinase C gamma (PKC gamma): function of neuron specific isotype. |journal=J. Biochem. |volume=132 |issue= 5 |pages= 683–7 |year= 2003 |pmid= 12417016 |doi=PBB_Controls
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