IRF1

Interferon regulatory factor 1, also known as IRF1, is a human gene.

PBB_Summary
section_title =
summary_text = IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [cite web | title = Entrez Gene: IRF1 interferon regulatory factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3659| accessdate = ]

ee also

*IRF2
*Interferon regulatory factors

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Harada H, Taniguchi T, Tanaka N |title=The role of interferon regulatory factors in the interferon system and cell growth control. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 641–50 |year= 1999 |pmid= 9865486 |doi=
*cite journal | author=Pitha PM, Au WC, Lowther W, "et al." |title=Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 651–8 |year= 1999 |pmid= 9865487 |doi=
*cite journal | author=Yu-Lee L |title=Stimulation of interferon regulatory factor-1 by prolactin. |journal=Lupus |volume=10 |issue= 10 |pages= 691–9 |year= 2002 |pmid= 11721695 |doi=
*cite journal | author=Pine R |title=IRF and tuberculosis. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 1 |pages= 15–25 |year= 2002 |pmid= 11846972 |doi= 10.1089/107999002753452629
*cite journal | author=Romeo G, Fiorucci G, Chiantore MV, "et al." |title=IRF-1 as a negative regulator of cell proliferation. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 1 |pages= 39–47 |year= 2002 |pmid= 11846974 |doi= 10.1089/107999002753452647
*cite journal | author=Cha Y, Sims SH, Romine MF, "et al." |title=Human interferon regulatory factor 1: intron-exon organization. |journal=DNA Cell Biol. |volume=11 |issue= 8 |pages= 605–11 |year= 1992 |pmid= 1382447 |doi=
*cite journal | author=Itoh S, Harada H, Nakamura Y, "et al." |title=Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31. |journal=Genomics |volume=10 |issue= 4 |pages= 1097–9 |year= 1991 |pmid= 1680796 |doi=
*cite journal | author=Harada H, Fujita T, Miyamoto M, "et al." |title=Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. |journal=Cell |volume=58 |issue= 4 |pages= 729–39 |year= 1989 |pmid= 2475256 |doi=
*cite journal | author=Maruyama M, Fujita T, Taniguchi T |title=Sequence of a cDNA coding for human IRF-1. |journal=Nucleic Acids Res. |volume=17 |issue= 8 |pages= 3292 |year= 1989 |pmid= 2726461 |doi=
*cite journal | author=Miyamoto M, Fujita T, Kimura Y, "et al." |title=Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. |journal=Cell |volume=54 |issue= 6 |pages= 903–13 |year= 1988 |pmid= 3409321 |doi=
*cite journal | author=Harada H, Takahashi E, Itoh S, "et al." |title=Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1500–9 |year= 1994 |pmid= 7507207 |doi=
*cite journal | author=Sharf R, Azriel A, Lejbkowicz F, "et al." |title=Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13063–9 |year= 1995 |pmid= 7768900 |doi=
*cite journal | author=Willman CL, Sever CE, Pallavicini MG, "et al." |title=Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. |journal=Science |volume=259 |issue= 5097 |pages= 968–71 |year= 1993 |pmid= 8438156 |doi=
*cite journal | author=Drew PD, Franzoso G, Becker KG, "et al." |title=NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression. |journal=J. Interferon Cytokine Res. |volume=15 |issue= 12 |pages= 1037–45 |year= 1997 |pmid= 8746784 |doi=
*cite journal | author=Ronco LV, Karpova AY, Vidal M, Howley PM |title=Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. |journal=Genes Dev. |volume=12 |issue= 13 |pages= 2061–72 |year= 1998 |pmid= 9649509 |doi=
*cite journal | author=Nozawa H, Oda E, Ueda S, "et al." |title=Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. |journal=Int. J. Cancer |volume=77 |issue= 4 |pages= 522–7 |year= 1998 |pmid= 9679752 |doi=
*cite journal | author=Schaper F, Kirchhoff S, Posern G, "et al." |title=Functional domains of interferon regulatory factor I (IRF-1). |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 147–57 |year= 1998 |pmid= 9742224 |doi=
*cite journal | author=Masumi A, Wang IM, Lefebvre B, "et al." |title=The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1810–20 |year= 1999 |pmid= 10022868 |doi=

External links

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