GNAQ

Guanine nucleotide binding protein (G protein), q polypeptide, also known as GNAQ, is a human gene.

PBB_Summary
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summary_text = Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230). [supplied by OMIM] [cite web | title = Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2776| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Raymond JR, Mukhin YV, Gelasco A, "et al." |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=
*cite journal | author=Van Oekelen D, Luyten WH, Leysen JE |title=5-HT2A and 5-HT2C receptors and their atypical regulation properties. |journal=Life Sci. |volume=72 |issue= 22 |pages= 2429–49 |year= 2003 |pmid= 12650852 |doi=
*cite journal | author=Lesch KP, Manji HK |title=Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain. |journal=Biol. Psychiatry |volume=32 |issue= 7 |pages= 549–79 |year= 1992 |pmid= 1333286 |doi=
*cite journal | author=Thomas CP, Dunn MJ, Mattera R |title=Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. |journal=Biochem. J. |volume=312 ( Pt 1) |issue= |pages= 151–8 |year= 1996 |pmid= 7492305 |doi=
*cite journal | author=Blin N, Yun J, Wess J |title=Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor. |journal=J. Biol. Chem. |volume=270 |issue= 30 |pages= 17741–8 |year= 1995 |pmid= 7629074 |doi=
*cite journal | author=Kabouridis PS, Waters ST, Escobar S, "et al." |title=Expression of GTP-binding protein alpha subunits in human thymocytes. |journal=Mol. Cell. Biochem. |volume=144 |issue= 1 |pages= 45–51 |year= 1995 |pmid= 7791744 |doi=
*cite journal | author=Allgeier A, Offermanns S, Van Sande J, "et al." |title=The human thyrotropin receptor activates G-proteins Gs and Gq/11. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 13733–5 |year= 1994 |pmid= 8188646 |doi=
*cite journal | author=Wedegaertner PB, Chu DH, Wilson PT, "et al." |title=Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. |journal=J. Biol. Chem. |volume=268 |issue= 33 |pages= 25001–8 |year= 1993 |pmid= 8227063 |doi=
*cite journal | author=Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A |title=Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. |journal=Endocrinology |volume=132 |issue= 6 |pages= 2484–90 |year= 1993 |pmid= 8504751 |doi=
*cite journal | author=Laugwitz KL, Allgeier A, Offermanns S, "et al." |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi=
*cite journal | author=Denker SP, McCaffery JM, Palade GE, "et al." |title=Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. |journal=J. Cell Biol. |volume=133 |issue= 5 |pages= 1027–40 |year= 1996 |pmid= 8655576 |doi=
*cite journal | author=Chen B, Leverette RD, Schwinn DA, Kwatra MM |title=Human G(alpha q): cDNA and tissue distribution. |journal=Biochim. Biophys. Acta |volume=1281 |issue= 2 |pages= 125–8 |year= 1996 |pmid= 8664309 |doi=
*cite journal | author=Dong Q, Shenker A, Way J, "et al." |title=Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene. |journal=Genomics |volume=30 |issue= 3 |pages= 470–75 |year= 1997 |pmid= 8825633 |doi= 10.1006/geno.1995.1267
*cite journal | author=Johnson GJ, Leis LA, Dunlop PC |title=Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. |journal=Biochem. J. |volume=318 ( Pt 3) |issue= |pages= 1023–31 |year= 1996 |pmid= 8836152 |doi=
*cite journal | author=Gomeza J, Mary S, Brabet I, "et al." |title=Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. |journal=Mol. Pharmacol. |volume=50 |issue= 4 |pages= 923–30 |year= 1996 |pmid= 8863838 |doi=
*cite journal | author=Petit A, Geoffroy P, Bélisle S |title=Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta. |journal=J. Soc. Gynecol. Investig. |volume=3 |issue= 6 |pages= 316–21 |year= 1997 |pmid= 8923415 |doi=
*cite journal | author=Petit A, Geoffroy P, Bélisle S |title=Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension. |journal=Life Sci. |volume=60 |issue= 12 |pages= 953–60 |year= 1997 |pmid= 9061052 |doi=
*cite journal | author=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957–64 |year= 1997 |pmid= 9152406 |doi=
*cite journal | author=Wise A, Parenti M, Milligan G |title=Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. |journal=FEBS Lett. |volume=407 |issue= 3 |pages= 257–60 |year= 1997 |pmid= 9175863 |doi=
*cite journal | author=Gabbeta J, Yang X, Kowalska MA, "et al." |title=Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8750–5 |year= 1997 |pmid= 9238049 |doi=

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