- Testicular receptor 4
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Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[1][2][3]
The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.
Contents
Interactions
Testicular receptor 4 has been shown to interact with
See also
References
- ^ "Entrez Gene: NR2C2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7182.
- ^ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (June 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44133.
- ^ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (July 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
- ^ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (December 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24715.
- ^ Shyr CR, Hu YC, Kim E, Chang C (April 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". J. Biol. Chem. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
- ^ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (March 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". J. Biol. Chem. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.
Further reading
- Hirose T, Fujimoto W, Tamaai T, et al. (1995). "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.". Mol. Endocrinol. 8 (12): 1667–80. doi:10.1210/me.8.12.1667. PMID 7708055.
- Young WJ, Smith SM, Chang C (1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily.". J. Biol. Chem. 272 (5): 3109–16. doi:10.1074/jbc.272.5.3109. PMID 9006963.
- Lee CH, Chinpaisal C, Wei LN (1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4.". J. Biol. Chem. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
- Lee YF, Shyr CR, Thin TH, et al. (2000). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24715.
- Wang X, Yeh S, Wu G, et al. (2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells.". J. Biol. Chem. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
- Yeung KC, Rose DW, Dhillon AS, et al. (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99896.
- Shyr CR, Hu YC, Kim E, Chang C (2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells.". J. Biol. Chem. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
- Tanabe O, Katsuoka F, Campbell AD, et al. (2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.". EMBO J. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126089.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Yang Y, Wang X, Dong T, et al. (2003). "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation.". J. Biol. Chem. 278 (9): 7709–17. doi:10.1074/jbc.M207116200. PMID 12486131.
- Lin WJ, Li J, Lee YF, et al. (2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4.". J. Biol. Chem. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.
- Takaesu G, Surabhi RM, Park KJ, et al. (2003). "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.". J. Mol. Biol. 326 (1): 105–15. doi:10.1016/S0022-2836(02)01404-3. PMID 12547194.
- Inui S, Lee YF, Chang E, et al. (2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.". J. Dermatol. Sci. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
- Ishitani T, Takaesu G, Ninomiya-Tsuji J, et al. (2004). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291846.
- Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1.". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223947.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
External links
Transcription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP)Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1(1.2) Basic helix-loop-helix (bHLH)ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1(1.3) bHLH-ZIP(1.4) NF-1(1.5) RF-X(1.6) Basic helix-span-helix (bHSH)(2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4)subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR)
subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX)
subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ))
subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)(2.2) Other Cys4(2.3) Cys2His2General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)(2.4) Cys6(2.5) Alternating composition(3) Helix-turn-helix domains (3.1) HomeodomainARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2)(3.2) Paired box(3.3) Fork head / winged helix(3.4) Heat Shock Factors(3.5) Tryptophan clusters(3.6) TEA domain(4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region(4.2) STAT(4.3) p53(4.4) MADS box(4.6) TATA binding proteins(4.7) High-mobility group(4.10) Cold-shock domainCSDA, YBX1(4.11) Runt(0) Other transcription factors (0.2) HMGI(Y)(0.3) Pocket domain(0.6) MiscellaneousCategories:- Human proteins
- Chromosome 3 gene stubs
- Intracellular receptors
- Transcription factors
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