6-pyruvoyltetrahydropterin synthase
- 6-pyruvoyltetrahydropterin synthase
In enzymology, a 6-pyruvoyltetrahydropterin synthase (EC number|4.2.3.12) is an enzyme that catalyzes the chemical reaction
:6- [(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl] -7,8-dihydropterin 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Hence, this enzyme has one substrate, 6- [(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl] -7,8-dihydropterin, and two products, 6-pyruvoyl-5,6,7,8-tetrahydropterin and triphosphate.
This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 6- [(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl] -7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming). Other names in common use include 2-amino-4-oxo-6- [(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl] -7,8-, and dihydroxypteridine triphosphate lyase. This enzyme participates in folate biosynthesis.
tructural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1Y13, PDB link|2A0S, PDB link|2DJ6, PDB link|2G64, and PDB link|2OBA.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|97089-82-2."
Gene Ontology (GO) codes
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