BCAR1

Breast cancer anti-estrogen resistance 1
PDB rendering based on 1wyx.
Available structures PDB 1wyx
Identifiers
Symbols	BCAR1; CAS; CAS1; CASS1; CRKAS; FLJ12176; FLJ45059; P130Cas
External IDs	OMIM: 602941 MGI: 108091 HomoloGene: 7674 GeneCards: BCAR1 Gene
Gene Ontology Molecular function • signal transducer activity • protein binding • SH3 domain binding • protein kinase binding • protein phosphatase binding Cellular component • ruffle • membrane fraction • cytoplasm • cytosol • cytosol • plasma membrane • focal adhesion • cell junction Biological process • regulation of cell growth • actin filament organization • cell adhesion • signal transduction • epidermal growth factor receptor signaling pathway • G-protein coupled receptor protein signaling pathway • G-protein coupled receptor protein signaling pathway • integrin-mediated signaling pathway • blood coagulation • cell proliferation • insulin receptor signaling pathway • cell migration • positive regulation of cell migration • regulation of apoptosis • platelet-derived growth factor receptor signaling pathway • nerve growth factor receptor signaling pathway • antigen receptor-mediated signaling pathway • T cell receptor signaling pathway • B cell receptor signaling pathway • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9564	12927
Ensembl	ENSG00000050820	ENSMUSG00000031955
UniProt	P56945	Q3TIT7
RefSeq (mRNA)	NM_001170714.1	NM_009954
RefSeq (protein)	NP_001164185.1	NP_034084
Location (UCSC)	Chr 16: 75.26 – 75.3 Mb	Chr 8: 114.23 – 114.27 Mb
PubMed search	[1]	[2]

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.^[1][2]

References

1. ^ Dorssers LC, van Agthoven T, Dekker A, van Agthoven TL, Kok EM (Oct 1993). "Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site". Mol Endocrinol 7 (7): 870–8. doi:10.1210/me.7.7.870. PMID 8413311. 
2. ^ Brinkman A, van der Flier S, Kok EM, Dorssers LC (Feb 2000). "BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells". J Natl Cancer Inst 92 (2): 112–20. doi:10.1093/jnci/92.2.112. PMID 10639512. 

Further reading

• Rozengurt E (1999). "Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists.". J. Cell. Physiol. 177 (4): 507–17. doi:10.1002/(SICI)1097-4652(199812)177:4<507::AID-JCP2>3.0.CO;2-K. PMID 10092204. 
• O'Neill GM, Fashena SJ, Golemis EA (2000). "Integrin signalling: a new Cas(t) of characters enters the stage.". Trends Cell Biol. 10 (3): 111–9. doi:10.1016/S0962-8924(99)01714-6. PMID 10675905. 
• Bouton AH, Riggins RB, Bruce-Staskal PJ (2001). "Functions of the adapter protein Cas: signal convergence and the determination of cellular responses.". Oncogene 20 (44): 6448–58. doi:10.1038/sj.onc.1204785. PMID 11607844. 
• Panetti TS (2002). "Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration.". Front. Biosci. 7: d143–50. doi:10.2741/panetti. PMID 11779709. 
• Mayer BJ, Hirai H, Sakai R (1995). "Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases.". Curr. Biol. 5 (3): 296–305. doi:10.1016/S0960-9822(95)00060-1. PMID 7780740. 
• Sakai R, Iwamatsu A, Hirano N, et al. (1994). "A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.". EMBO J. 13 (16): 3748–56. PMC 395286. PMID 8070403. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395286. 
• Vuori K, Hirai H, Aizawa S, Ruoslahti E (1996). "Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.". Mol. Cell. Biol. 16 (6): 2606–13. PMC 231251. PMID 8649368. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231251. 
• Law SF, Estojak J, Wang B, et al. (1996). "Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.". Mol. Cell. Biol. 16 (7): 3327–37. PMC 231327. PMID 8668148. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231327. 
• Khwaja A, Hallberg B, Warne PH, Downward J (1996). "Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins.". Oncogene 12 (12): 2491–8. PMID 8700507. 
• Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.". J. Biol. Chem. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278. 
• Garton AJ, Flint AJ, Tonks NK (1996). "Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.". Mol. Cell. Biol. 16 (11): 6408–18. PMC 231642. PMID 8887669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231642. 
• Liu F, Hill DE, Chernoff J (1997). "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).". J. Biol. Chem. 271 (49): 31290–5. doi:10.1074/jbc.271.49.31290. PMID 8940134. 
• Astier A, Avraham H, Manie SN, et al. (1997). "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas.". J. Biol. Chem. 272 (1): 228–32. doi:10.1074/jbc.272.1.228. PMID 8995252. 
• Jücker M, McKenna K, da Silva AJ, et al. (1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling.". J. Biol. Chem. 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID 8999909. 
• Manié SN, Beck AR, Astier A, et al. (1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.". J. Biol. Chem. 272 (7): 4230–6. doi:10.1074/jbc.272.7.4230. PMID 9020138. 
• Schlaepfer DD, Hunter T (1997). "Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.". J. Biol. Chem. 272 (20): 13189–95. doi:10.1074/jbc.272.20.13189. PMID 9148935. 
• Manié SN, Astier A, Haghayeghi N, et al. (1997). "Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2.". J. Biol. Chem. 272 (25): 15636–41. doi:10.1074/jbc.272.25.15636. PMID 9188452. 
• Garton AJ, Burnham MR, Bouton AH, Tonks NK (1997). "Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition.". Oncogene 15 (8): 877–85. doi:10.1038/sj.onc.1201279. PMID 9285683. 
• Kanda H, Mimura T, Morino N, et al. (1997). "Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk.". Eur. J. Immunol. 27 (8): 2113–7. doi:10.1002/eji.1830270840. PMID 9295052. 

External links

• Bcar1 Info with links in the Cell Migration Gateway