ACTG1


ACTG1
Actin, gamma 1

PDB rendering based on 1atn.
Identifiers
Symbols ACTG1; ACT; ACTG; DFNA20; DFNA26
External IDs OMIM102560 MGI87906 HomoloGene74402 GeneCards: ACTG1 Gene
RNA expression pattern
PBB GE ACTG1 211983 x at tn.png
PBB GE ACTG1 201550 x at tn.png
PBB GE ACTG1 211970 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 71 11465
Ensembl ENSG00000184009 ENSMUSG00000062825
UniProt P63261 n/a
RefSeq (mRNA) NM_001199954.1 NM_009609.2
RefSeq (protein) NP_001186883.1 NP_033739.1
Location (UCSC) Chr 17:
79.48 – 79.48 Mb
Chr 11:
120.21 – 120.21 Mb
PubMed search [1] [2]

Actin, gamma 1, also known as ACTG1, is a gene.

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells.[1]

Contents

Interactions

ACTG1 has been shown to interact with TMSB4X[2][3] and CAP1.[4]

See also

References

  1. ^ "Entrez Gene: ACTG1 actin, gamma 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=71. 
  2. ^ Hertzog, Maud; van Heijenoort Carine, Didry Dominique, Gaudier Martin, Coutant Jérôme, Gigant Benoît, Didelot Gérard, Préat Thomas, Knossow Marcel, Guittet Eric, Carlier Marie-France (May. 2004). "The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly". Cell (United States) 117 (5): 611–23. doi:10.1016/S0092-8674(04)00403-9. ISSN 0092-8674. PMID 15163409. 
  3. ^ Van Troys, M; Dewitte D, Goethals M, Carlier M F, Vandekerckhove J, Ampe C (Jan. 1996). "The actin binding site of thymosin beta 4 mapped by mutational analysis". EMBO J. (ENGLAND) 15 (2): 201–10. ISSN 0261-4189. PMC 449934. PMID 8617195. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=449934. 
  4. ^ Hubberstey, A; Yu G, Loewith R, Lakusta C, Young D (Jun. 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". J. Cell. Biochem. (UNITED STATES) 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. ISSN 0730-2312. PMID 8761950. 

Further reading




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