Philippa Marrack

Infobox Scientist


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name = Philippa "Pippa" Marrack
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birth_place = England
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residence = Colorado, United States
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alma_mater = Cambridge University
doctoral_advisor = Alan Munro
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known_for = T cells, autoimmune disease
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Philippa "Pippa" Marrack FRS is a biologist, known for her research into T cells and autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome. She collaborates with her husband, John W. Kappler.

Biography

Marrack was born in England, and completed both undergraduate and Ph.D. work at Cambridge University, New Hall. During her Ph.D., she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to work on T cells. She then did a postdoc with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by the National Jewish Medical and Research Center, Denver, Colorado and the University of Colorado.

ignificant papers

* J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," "Cell", v.49, n.2, pp. 273-80 (1987)
* P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," "Science", v.248 (4956), pp. 705-11 (1990).
* J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," "Nature", 332 (6159): pp. 35-40 (1988).
* J. White, "et al" (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," "Cell", v.56, n.1, pp. 27-35 (1989).

Awards

* 1986 - Appointed Investigator, Howard Hughes Medical Institute
* 1987 - Fellow (elected), Royal Society
* 1989 - Elected member, National Academy of Sciences
* 1990 - Royal Society Wellcome Foundation Prize
* 1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
* 1994/95 - Louisa Gross Horwitz Prize
* 2003 - Lifetime Achievement Award, American Association of Immunologists [ [http://www.nationaljewish.org/news/y2003/marrack-aai-lifetime.aspx "Philippa Marack To Be Honored for Lifetime Achievement in Immunology"] , May 4, 2003.] [ [http://www.aai.org/Awards/award_history.htm AAI Award History] ]
* 2004 - L'Oreal UNESCO Women in Science Award
* 2005 - Pearl Meister Greengard Prize [ [http://newswire.rockefeller.edu/?id=426&page=engine Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize"] , Nov. 2, 2005.]
* Rabbi Shai Shackner Prize (University of Jerusalem)

Notes

Further reading

* [http://www.hhmi.org/research/investigators/marrack.html HHMI Profile of work]
* [http://www.hhmi.org/becoming/marrack.html "Becoming a Scientist"] , Philippa Marrack, HHMI
* [http://www.sciencewatch.com/interviews/philippa_marrack.htm "Philippa Marrack Targets T Cells and Autoimmune Disease"] , "ScienceWatch"
* Christine Bahls, "Philippa Marrack", 'The Scientist" v.18, n.6, p.13 (2004).
* "Profile: Philippa Marrack", "Nature Medicine", v.10, n.12.

External links

* [http://www.kmlab.njc.org/ Kappler/Marrack Lab]