Somatostatin receptor 4

Somatostatin receptor 4

Somatostatin receptor 4, also known as SSTR4, is a human gene.cite web | title = Entrez Gene: SSTR4 somatostatin receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6754| accessdate = ]

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summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.cite web | title = Entrez Gene: SSTR4 somatostatin receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6754| accessdate = ]

ee also

* Somatostatin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Patel YC |title=Somatostatin and its receptor family. |journal=Frontiers in neuroendocrinology |volume=20 |issue= 3 |pages= 157–98 |year= 1999 |pmid= 10433861 |doi= 10.1006/frne.1999.0183
*cite journal | author=Yamada Y, Post SR, Wang K, "et al." |title=Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 251–5 |year= 1992 |pmid= 1346068 |doi=
*cite journal | author=Demchyshyn LL, Srikant CB, Sunahara RK, "et al." |title=Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. |journal=Mol. Pharmacol. |volume=43 |issue= 6 |pages= 894–901 |year= 1993 |pmid= 8100352 |doi=
*cite journal | author=Yasuda K, Espinosa R, Davis EM, "et al." |title=Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2. |journal=Genomics |volume=17 |issue= 3 |pages= 785–6 |year= 1993 |pmid= 8244401 |doi= 10.1006/geno.1993.1410
*cite journal | author=Yamada Y, Kagimoto S, Kubota A, "et al." |title=Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 844–52 |year= 1993 |pmid= 8373420 |doi=
*cite journal | author=Kaupmann K, Bruns C, Hoyer D, "et al." |title=Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. |journal=FEBS Lett. |volume=331 |issue= 1-2 |pages= 53–9 |year= 1993 |pmid= 8405411 |doi=
*cite journal | author=Yamada Y, Stoffel M, Espinosa R, "et al." |title=Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. |journal=Genomics |volume=15 |issue= 2 |pages= 449–52 |year= 1993 |pmid= 8449518 |doi= 10.1006/geno.1993.1088
*cite journal | author=Rohrer L, Raulf F, Bruns C, "et al." |title=Cloning and characterization of a fourth human somatostatin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 9 |pages= 4196–200 |year= 1993 |pmid= 8483934 |doi=
*cite journal | author=Xu Y, Song J, Bruno JF, Berelowitz M |title=Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. |journal=Biochem. Biophys. Res. Commun. |volume=193 |issue= 2 |pages= 648–52 |year= 1993 |pmid= 8512564 |doi=
*cite journal | author=Fukusumi S, Kitada C, Takekawa S, "et al." |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157–63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252
*cite journal | author=de Lecea L, Ruiz-Lozano P, Danielson PE, "et al." |title=Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. |journal=Genomics |volume=42 |issue= 3 |pages= 499–506 |year= 1997 |pmid= 9205124 |doi= 10.1006/geno.1997.4763
*cite journal | author=Jaïs P, Terris B, Ruszniewski P, "et al." |title=Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. |journal=Eur. J. Clin. Invest. |volume=27 |issue= 8 |pages= 639–44 |year= 1997 |pmid= 9279525 |doi=
*cite journal | author=Sharma K, Patel YC, Srikant CB |title=C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 82–90 |year= 1999 |pmid= 9892014 |doi=
*cite journal | author=Forssell-Aronsson EB, Nilsson O, Bejegård SA, "et al." |title=111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors. |journal=J. Nucl. Med. |volume=41 |issue= 4 |pages= 636–42 |year= 2000 |pmid= 10768564 |doi=
*cite journal | author=Zatelli MC, Tagliati F, Taylor JE, "et al." |title=Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2161–9 |year= 2001 |pmid= 11344221 |doi=
*cite journal | author=Talme T, Ivanoff J, Hägglund M, "et al." |title=Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 71–9 |year= 2001 |pmid= 11472428 |doi=
*cite journal | author=Pasquali D, Notaro A, Esposito D, "et al." |title= [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy] |journal=Minerva Endocrinol. |volume=26 |issue= 3 |pages= 175–9 |year= 2002 |pmid= 11753241 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Papotti M, Bongiovanni M, Volante M, "et al." |title=Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. |journal=Virchows Arch. |volume=440 |issue= 5 |pages= 461–75 |year= 2002 |pmid= 12021920 |doi= 10.1007/s00428-002-0609-x

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1298 IUPHAR Receptor Database - Somatostatin Receptors]
*

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