Glucosylceramidase

Pfam_box
Symbol = Glyco_hydro_30
Name = O-Glycosyl hydrolase family 30


width =
caption =
Pfam= PF02055
InterPro= IPR001139
SMART=
Prosite =
SCOP = 1nof
TCDB =
OPM family=
OPM protein= 1ogs
PDB=PDB3|1y7vA:40-533 PDB3|1ogsA:40-533 PDB3|1nofA:31-383

In enzymology, a glucosylceramidase (EC number|3.2.1.45) is an enzyme that catalyzes the chemical reaction

:D-glucosyl-N-acylsphingosine + H₂O $ightleftharpoons$ D-glucose + N-acylsphingosine

Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H₂O, whereas its two products are D-glucose and N-acylsphingosine.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include psychosine hydrolase, glucosphingosine glucosylhydrolase, GlcCer-beta-glucosidase, beta-D-glucocerebrosidase, glucosylcerebrosidase, beta-glucosylceramidase, ceramide glucosidase, glucocerebrosidase, glucosylsphingosine beta-glucosidase, and glucosylsphingosine beta-D-glucosidase. This enzyme participates in sphingolipid metabolism and glycan structures - degradation.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1OGS, PDB link|1Y7V, PDB link|2F61, PDB link|2J25, PDB link|2NSX, PDB link|2NT0, PDB link|2NT1, PDB link|2V3D, and PDB link|2V3E.

Human proteins containing this domain

GBA;

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37228-64-1."

Gene Ontology (GO) codes