Arylformamidase

arylformamidase
Identifiers
EC number	3.5.1.9
CAS number	156229-75-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, an arylformamidase (EC 3.5.1.9) is an enzyme that catalyzes the chemical reaction

N-formyl-L-kynurenine + H₂O $\rightleftharpoons$ formate + L-kynurenine

Thus, the two substrates of this enzyme are N-formyl-L-kynurenine and H₂O, whereas its two products are formate and L-kynurenine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is aryl-formylamine amidohydrolase. Other names in common use include kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, and formamidase II. This enzyme participates in tryptophan metabolism and glyoxylate and dicarboxylate metabolism.

References

• HAYAISHI O, STANIER RY (1951). "The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway". J. Bacteriol. 62 (6): 691–709. PMC 386191. PMID 14907621. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=386191. 
• JAKOBY WB (1954). "Kynurenine formamidase from Neurospora". J. Biol. Chem. 207 (2): 657–63. PMID 13163050. 
• MEHLER AH, KNOX WE (1950). "The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine". J. Biol. Chem. 187 (1): 431–8. PMID 14794728. 

G

G→pyruvate →citrate	glycine→serine→ Serine hydroxymethyltransferase · Serine dehydratase glycine→creatine: Guanidinoacetate N-methyltransferase · Creatine kinase alanine→ Alanine transaminase cysteine→ D-cysteine desulfhydrase threonine→ L-threonine dehydrogenase
G→glutamate→ α-ketoglutarate	HISTIDINE→ Histidine ammonia-lyase · Urocanate hydratase · Formiminotransferase cyclodeaminase proline→ Proline oxidase · Pyrroline-5-carboxylate reductase · 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 · PYCR1 arginine→ Ornithine aminotransferase · Ornithine decarboxylase · Agmatinase →alpha-ketoglutarate→TCA Glutamate dehydrogenase Other cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase · Glutathione synthetase · Gamma-glutamyl transpeptidase glutamate→glutamine: Glutamine synthetase · Glutaminase
G→propionyl-CoA→ succinyl-CoA	VALINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · Enoyl-CoA hydratase · 3-hydroxyisobutyryl-CoA hydrolase · 3-hydroxyisobutyrate dehydrogenase · Methylmalonate semialdehyde dehydrogenase ISOLEUCINE→ Branched chain aminotransferase · Branched-chain alpha-keto acid dehydrogenase complex · 3-hydroxy-2-methylbutyryl-CoA dehydrogenase METHIONINE→ generation of homocysteine: Methionine adenosyltransferase · Adenosylhomocysteinase regeneration of methionine: Methionine synthase/Homocysteine methyltransferase · Betaine-homocysteine methyltransferase conversion to cysteine: Cystathionine beta synthase · Cystathionine gamma-lyase THREONINE→ Threonine aldolase →succinyl-CoA→TCA Propionyl-CoA carboxylase · Methylmalonyl CoA epimerase · Methylmalonyl-CoA mutase
G→fumarate	PHENYLALANINE→tyrosine→ Phenylalanine hydroxylase · Tyrosine aminotransferase · 4-Hydroxyphenylpyruvate dioxygenase · Homogentisate 1,2-dioxygenase · Fumarylacetoacetate hydrolase tyrosine→melanin: Tyrosinase
G→oxaloacetate	asparagine→aspartate→ Asparaginase/Asparagine synthetase · Aspartate transaminase

M: MET mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)