Triclabendazole

Triclabendazole

Drugbox
IUPAC_name = 5-chloro-6- (2,3-dichlorophenoxy) -2-methylsulfanyl- 3H-benzoimidazole



CAS_number=68786-66-3
ATC_prefix=P02
ATC_suffix=BX04
PubChem=50248
DrugBank=
C=14 | H=9 | Cl=3 | N=2 | O=1 | S=1
molecular_weight = 359.658
bioavailability= ?
metabolism = oxidation to the sulfone and sulfoxide parent compound
elimination_half-life= 22 - 24 hs
excretion = >95% in faeces, 2% in urine, and < 1% in milk
pregnancy_category = ?
legal_status = ?
routes_of_administration= ?

Triclabendazole (commercial name Fasinex) is a member of the Benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group.

Triclabendazole displays high efficacy against both immature and adult liver fluke.

It is generally accepted that benzimidazoles like triclabendazole bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.

External links


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • triclabendazole — noun A benzimidazole anthelmintic, unusual in having a chlorinated benzene ring but no carbamate group, that displays a high efficacy against the liver fluke …   Wiktionary

  • triclabendazole — tri·cla·ben·da·zole (tri″klə benґdə zōl) a benzimidazole used as an anthelmintic in the treatment of fascioliasis and paragonimiasis; administered orally …   Medical dictionary

  • Fasciolosis — Classification and external resources ICD 10 B66.3 ICD 9 121.3 …   Wikipedia

  • Fascioloides magna — Taxobox name = Giant liver fluke regnum = Animalia phylum = Platyhelminthes classis = Trematoda subclassis = Digenea ordo = Echinostomida familia = Fasciolidae genus = Fascioloides binomial = Fascioloides magna binomial authority = Bassi, 1875… …   Wikipedia

  • Fasciola hepatica — adult worm Scientific classification …   Wikipedia

  • Triclabendazol — Strukturformel Allgemeines Freiname Triclabendazol Andere Namen …   Deutsch Wikipedia

  • Fascioliasis — Saltar a navegación, búsqueda Fascioliasis Clasificación y recursos externos Aviso médico …   Wikipedia Español

  • Fasciolose — Classification et ressources externes CIM 10 B66.3 CIM 9 121.3 DiseasesDB …   Wikipédia en Français

  • Novartis — Sandoz Laboratories redirects here. For the new Sandoz company founded in 2003, see Sandoz. Novartis International AG Type Public AG Traded as SIX:  …   Wikipedia

  • Anthelmintic — Anthelmintics or antihelminthics are drugs that expel parasitic worms (helminths) from the body, by either stunning or killing them. They may also be called vermifuges (stunning) or vermicides (killing).Pharmaceutical classesExamples of… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”