Glutathione gamma-glutamylcysteinyltransferase

In enzymology, a glutathione gamma-glutamylcysteinyltransferase (EC number|2.3.2.15) is an enzyme that catalyzes the chemical reaction

:glutathione + [Glu(-Cys)] n-Gly $ightleftharpoons$ Gly + [Glu(-Cys)] n⁺1-Gly

Thus, the two substrates of this enzyme are glutathione and [Glu(-Cys)] n-Gly, whereas its two products are Gly and [Glu(-Cys)] n+1-Gly.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase. Other names in common use include phytochelatin synthase, and gamma-glutamylcysteine dipeptidyl transpeptidase.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2BTW and PDB link|2BU3.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|125390-02-5."

Gene Ontology (GO) codes