IC3b

IC3b

iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b [Robbins Basic Pathology 8th ed 2007. R Cotran, S Robbins, V Kumar, J Perkins. W.B. Saunders Company.] that still opsonizes microbes, but cannot associate with factor B. Thus preventing amplification of the of the complement cascade or activation through the alternative pathway.

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