LPHN2

Latrophilin 2, also known as LPHN2, is a human gene.cite web | title = Entrez Gene: LPHN2 latrophilin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23266| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.cite web | title = Entrez Gene: LPHN2 latrophilin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23266| accessdate = ]

ee also

* Latrophilin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Südhof TC |title=alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. |journal=Annu. Rev. Neurosci. |volume=24 |issue= |pages= 933–62 |year= 2001 |pmid= 11520923 |doi= 10.1146/annurev.neuro.24.1.933
*cite journal | author=Ushkaryov YA, Volynski KE, Ashton AC |title=The multiple actions of black widow spider toxins and their selective use in neurosecretion studies. |journal=Toxicon |volume=43 |issue= 5 |pages= 527–42 |year= 2004 |pmid= 15066411 |doi= 10.1016/j.toxicon.2004.02.008
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=White GR, Varley JM, Heighway J |title=Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. |journal=Oncogene |volume=17 |issue= 26 |pages= 3513–9 |year= 1999 |pmid= 10030676 |doi= 10.1038/sj.onc.1202487
*cite journal | author=White GR, Varley JM, Heighway J |title=Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. |journal=Biochim. Biophys. Acta |volume=1491 |issue= 1-3 |pages= 75–92 |year= 2000 |pmid= 10760572 |doi=
*cite journal | author=Kreienkamp HJ, Zitzer H, Gundelfinger ED, "et al." |title=The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32387–90 |year= 2000 |pmid= 10964907 |doi= 10.1074/jbc.C000490200
*cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, "et al." |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Clark TA, Schweitzer AC, Chen TX, "et al." |title=Discovery of tissue-specific exons using comprehensive human exon microarrays. |journal=Genome Biol. |volume=8 |issue= 4 |pages= R64 |year= 2007 |pmid= 17456239 |doi= 10.1186/gb-2007-8-4-r64

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes