Cyclic AMP receptors

Slime mold cyclic AMP receptor
Identifiers
Symbol	Dicty_CAR
Pfam	PF05462
Pfam clan	CL0192
InterPro	IPR000848
PROSITE	PDOC00691
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.

The cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes^[1][2][3]. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.

See also

• cAMP receptor protein

References

1. ^ Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). "A chemoattractant receptor controls development in Dictyostelium discoideum". Science 241 (4872): 1467–1472. doi:10.1126/science.3047871. PMID 3047871. 
2. ^ Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum". Genes Dev. 7 (2): 262–272. doi:10.1101/gad.7.2.262. PMID 8436297. 
3. ^ Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL (1993). "Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development". Genes Dev. 7 (2): 273–282. doi:10.1101/gad.7.2.273. PMID 8382181. 

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.v · Categories: G protein coupled receptors Protein domains Protein families Membrane proteins Transmembrane receptor stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Up for Breakfast Shivering Sherlocks Look at other dictionaries: cyclic AMP — (= cAMP) 3 5 cyclic ester of AMP. The first second messenger hormone signalling system to be characterized. Generated from ATP by the action of adenyl cyclase that is coupled to hormone receptors by G proteins (GTP binding proteins). cAMP… …   Dictionary of molecular biology Cyclic adenosine monophosphate — Identifiers …   Wikipedia Cyclic guanosine monophosphate — IUPAC name 2 amino 9 [(1S,6R,8R,9R) 3,9 dihydroxy 3 oxo 2,4,7 trioxa 3λ5 phosphabicyclo[4 …   Wikipedia List of A1 genes, proteins or receptors — This is a list of genes, proteins or receptors named A1 or Alpha 1 : Actin, alpha 1 Actinin, alpha 1 Adaptor related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family, member A1 Aldehyde dehydrogenase 4 family, member A1 Aldehyde… …   Wikipedia G protein-coupled receptor — G protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules …   Wikipedia Signal transduction — In biology, signal transduction refers to any process by which a cell converts one kind of signal or stimulus into another. Most processes of signal transduction involve ordered sequences of biochemical reactions inside the cell, which are… …   Wikipedia cell — cell1 cell like, adj. /sel/, n. 1. a small room, as in a convent or prison. 2. any of various small compartments or bounded areas forming part of a whole. 3. a small group acting as a unit within a larger organization: a local cell of the… …   Universalium Adenosine triphosphate — For the Japanese rock band, see Adenosine Tri Phosphate (band). Adenosine triphosphate …   Wikipedia FSH-receptor — Follicle stimulating hormone receptor PDB rendering based on 1xwd …   Wikipedia Dopamine receptor D1 — Identifiers Symbols DRD1; DADR; DRD1A External IDs OMIM: …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”