CTBP1

CTBP1

C-terminal binding protein 1, also known as CTBP1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [cite web | title = Entrez Gene: CTBP1 C-terminal binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1487| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chinnadurai G |title=CtBP, an unconventional transcriptional corepressor in development and oncogenesis. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 213–24 |year= 2002 |pmid= 11864595 |doi=
*cite journal | author=Schaeper U, Boyd JM, Verma S, "et al." |title=Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 23 |pages= 10467–71 |year= 1995 |pmid= 7479821 |doi=
*cite journal | author=Boyd JM, Subramanian T, Schaeper U, "et al." |title=A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. |journal=EMBO J. |volume=12 |issue= 2 |pages= 469–78 |year= 1993 |pmid= 8440238 |doi=
*cite journal | author=Katsanis N, Fisher EM |title=A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. |journal=Genomics |volume=47 |issue= 2 |pages= 294–9 |year= 1998 |pmid= 9479502 |doi= 10.1006/geno.1997.5115
*cite journal | author=Schaeper U, Subramanian T, Lim L, "et al." |title=Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8549–52 |year= 1998 |pmid= 9535825 |doi=
*cite journal | author=Sundqvist A, Sollerbrant K, Svensson C |title=The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex. |journal=FEBS Lett. |volume=429 |issue= 2 |pages= 183–8 |year= 1998 |pmid= 9650586 |doi=
*cite journal | author=Fuks F, Milner J, Kouzarides T |title=BRCA2 associates with acetyltransferase activity when bound to P/CAF. |journal=Oncogene |volume=17 |issue= 19 |pages= 2531–4 |year= 1998 |pmid= 9824164 |doi= 10.1038/sj.onc.1202475
*cite journal | author=Sewalt RG, Gunster MJ, van der Vlag J, "et al." |title=C-Terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 777–87 |year= 1999 |pmid= 9858600 |doi=
*cite journal | author=Li S, Chen PL, Subramanian T, "et al." |title=Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11334–8 |year= 1999 |pmid= 10196224 |doi=
*cite journal | author=Postigo AA, Dean DC |title=ZEB represses transcription through interaction with the corepressor CtBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6683–8 |year= 1999 |pmid= 10359772 |doi=
*cite journal | author=Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B |title=Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3392–403 |year= 1999 |pmid= 10369679 |doi= 10.1093/emboj/18.12.3392
*cite journal | author=Holmes M, Turner J, Fox A, "et al." |title=hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23491–8 |year= 1999 |pmid= 10438528 |doi=
*cite journal | author=Furusawa T, Moribe H, Kondoh H, Higashi Y |title=Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8581–90 |year= 2000 |pmid= 10567582 |doi=
*cite journal | author=Yu X, Baer R |title=Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18541–9 |year= 2000 |pmid= 10764811 |doi= 10.1074/jbc.M909494199
*cite journal | author=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594–602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200
*cite journal | author=Melhuish TA, Wotton D |title=The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39762–6 |year= 2001 |pmid= 10995736 |doi= 10.1074/jbc.C000416200
*cite journal | author=Zhang CL, McKinsey TA, Lu JR, Olson EN |title=Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 35–9 |year= 2001 |pmid= 11022042 |doi= 10.1074/jbc.M007364200
*cite journal | author=Izutsu K, Kurokawa M, Imai Y, "et al." |title=The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. |journal=Blood |volume=97 |issue= 9 |pages= 2815–22 |year= 2001 |pmid= 11313276 |doi=
*cite journal | author=Palmer S, Brouillet JP, Kilbey A, "et al." |title=Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25834–40 |year= 2001 |pmid= 11328817 |doi= 10.1074/jbc.M102343200
*cite journal | author=Schuierer M, Hilger-Eversheim K, Dobner T, "et al." |title=Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27944–9 |year= 2001 |pmid= 11373277 |doi= 10.1074/jbc.M100070200

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • CTBP2 — C terminal binding protein 2, also known as CTBP2, is a human gene.cite web | title = Entrez Gene: CTBP2 C terminal binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1488| accessdate = ] PBB …   Wikipedia

  • SUMO network — consists of enzymes and substrates involved in the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to substrates). Network membersThe SUMO network members (gene name and aliases) as published in the… …   Wikipedia

  • KLF12 — Kruppel like factor 12, also known as KLF12, is a human gene.cite web | title = Entrez Gene: KLF12 Kruppel like factor 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=11278| accessdate = ] PBB Summary… …   Wikipedia

  • Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2. [1] …   Wikipedia

  • EEF1D — Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), also known as EEF1D, is a human gene. PBB Summary section title = summary text = This gene encodes a subunit of the elongation factor 1 complex, which is… …   Wikipedia

  • NRIP1 — Nuclear receptor interacting protein 1 Rendering of 2GPO …   Wikipedia

  • MLL (gene) — HRX redirects here. For the bank holding, see Hypo Real Estate. Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila) PDB rendering based on 2j2s …   Wikipedia

  • Histona deacetilasa 1 — HUGO 4852 Símbolo HDAC1 Símbolos alt. DKFZp686H12203; GON 10; HD1; RPD3; RPD3L1 …   Wikipedia Español

  • TGIF1 — Proteína homeótica TGIF1 HUGO 11776 Símbolo TGIF1 Símbolos alt. TGIF; HPE4; MGC39747; MGC5066 …   Wikipedia Español

  • IKZF1 — Proteína de unión a ADN Ikaros HUGO 13176 Símbolo IKZF1 Símbolos alt. IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk 1 …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”