NPR1

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Identifiers
Symbols	NPR1; ANPRA; ANPa; GUC2A; GUCY2A; NPRA
External IDs	OMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1 Gene
EC number	4.6.1.2
Gene Ontology Molecular function • nucleotide binding • guanylate cyclase activity • protein kinase activity • receptor activity • ATP binding • GTP binding • peptide receptor activity, G-protein coupled • transferase activity, transferring phosphorus-containing groups • natriuretic peptide receptor activity • peptide hormone binding • protein kinase binding • hormone binding Cellular component • plasma membrane • integral to plasma membrane Biological process • cGMP biosynthetic process • cell surface receptor linked signaling pathway • receptor guanylyl cyclase signaling pathway • body fluid secretion • regulation of blood pressure • negative regulation of angiogenesis • negative regulation of cell growth • positive regulation of cGMP biosynthetic process • intracellular signal transduction • positive regulation of urine volume • positive regulation of renal sodium excretion • regulation of vasodilation • dopamine metabolic process • regulation of vascular permeability • negative regulation of smooth muscle cell proliferation • regulation of blood vessel size Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4881	18160
Ensembl	ENSG00000169418	ENSMUSG00000027931
UniProt	P16066	Q2TAY4
RefSeq (mRNA)	NM_000906	NM_008727.5
RefSeq (protein)	NP_000897	NP_032753.5
Location (UCSC)	Chr 1: 153.65 – 153.67 Mb	Chr 3: 90.25 – 90.27 Mb
PubMed search	[1]	[2]

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).^[1]

It is localized in the kidney^[2] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.^[2]

References

1. ^ "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4881. 
2. ^ ^{a b} BioGPS > NPR1 Retrieved Nov 2010

Further reading

• Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097. 
• Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 3 (11): 1085–91. PMID 12506509. 
• Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067. 
• Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069. 

See also

• Atrial natriuretic peptide receptor

External links

• MeSH NPR1+protein,+human

Opioid receptors

Delta · Kappa · Mu · Nociceptin

Other neuropeptide receptors

Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin

Type I cytokine receptor

GH · Prolactin

Enzyme-linked receptor

Atrial natriuretic factor (NPR1, NPR2)

Other

Sigma (1, 2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)